Pannexin channels in inflammation and tumorigenesis [PDF]
Frontiers in Cell and Developmental BiologyPannexin (Panx) channels are oligomeric heptamers of PANX proteins, comprising Panx1, Panx2 and Panx3. These channels facilitate the extracellular release of signaling molecules up to 1.5 kDa in size, including adenosine triphosphate (ATP), amino acids ...
Mengmeng Jiang +5 more
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A quantized mechanism for activation of pannexin channels [PDF]
Nature Communications, 2017 Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance
Yu-Hsin Chiu +10 more
doaj +5 more sources
ATP-release pannexin channels are gated by lysophospholipids [PDF]
eLife, 2023 In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze +11 more
doaj +5 more sources
Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions [PDF]
Neural Regeneration Research, 2021 Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclusive ...
Monica L Acosta +6 more
doaj +2 more sources
Role of astroglial hemichannels and pannexons in Memory and Neurodegenerative diseases [PDF]
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana +3 more
doaj +6 more sources
Deacetylation as a receptor-regulated direct activation switch for pannexin channels [PDF]
Nature Communications, 2021 Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves ...
Yu-Hsin Chiu +14 more
doaj +2 more sources
Connexins and pannexins: from biology towards clinical targets [PDF]
Swiss Medical Weekly, 2016 Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the ...
Paolo Meda, Jacques-Antoine Haefliger
doaj +3 more sources
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton [PDF]
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
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High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure [PDF]
EBioMedicine, 2016 Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (CaV1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM).
Gerhard P. Dahl +6 more
doaj +2 more sources
The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]
J Trop MedChagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc +2 more sources