Results 91 to 100 of about 7,055 (209)

Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival [PDF]

Nature Cell Biology, 2015
During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier remain unknown.
Furlow, Paul W, Zhang, Steven, Soong, T David, Halberg, Nils, Goodarzi, Hani, Mangrum, Creed, Wu, Y Gloria, Elemento, Olivier, Tavazoie, Sohail F   +8 more
openaire   +4 more sources

Extracellular chloride is required for efficient activation of secondary signalling pathways during platelet aggregation [PDF]

, 2017
Anion channels perform a diverse range of functions and have been implicated in ATP release, volume regulation and phosphatidylserine exposure. Platelets have been shown to express several anion channels however their function is incompletely understood.
Harper, Matthew T., Pugh, Nicholas, Taylor, Kirk A., Wilson, Darren   +3 more
core   +3 more sources

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives

The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.
Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu, Laura Beth Payne, Robert G. Gourdie   +2 more
wiley   +1 more source

The two faces of pannexins: new roles in inflammation and repair

Journal of Inflammation Research, 2018
Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj  

Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice

Frontiers in Molecular Neuroscience, 2018
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate of memory formation.
Ivana Gajardo, Claudia S. Salazar, Daniela Lopez-Espíndola, Daniela Lopez-Espíndola, Carolina Estay, Carolina Estay, Carolina Flores-Muñoz, Claudio Elgueta, Arlek M. Gonzalez-Jamett, Arlek M. Gonzalez-Jamett, Agustín D. Martínez, Pablo Muñoz, Pablo Muñoz, Pablo Muñoz, Álvaro O. Ardiles, Álvaro O. Ardiles, Álvaro O. Ardiles   +16 more
doaj   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases

Frontiers in Cellular Neuroscience, 2019
A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter composition of the extracellular ...
Lucila Brocardo, Luis Ernesto Acosta, Ana Paula Piantanida, Lorena Rela   +3 more
doaj   +1 more source

Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration. [PDF]

, 2016
Our previous reports indicate that ligand-induced αVβ3 integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes.
Alvarez, A., Burgos-Bravo, F., Cárdenas, A., Kong, M., Lagos-Cabré, R., Leyton, L., Quest, A.F., Schneider, P.   +7 more
core   +2 more sources

Revisiting multimodal activation and channel properties of Pannexin 1 [PDF]

Journal of General Physiology, 2017
Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activation results in the release of nucleotides such as adenosine triphosphate and uridine triphosphate. Thus, these channels have been implicated in diverse physiological and pathological functions associated with purinergic signaling, such as ...
Yu-Hsin Chiu, Michael S. Schappe, Bimal N. Desai, Douglas A. Bayliss   +3 more
openaire   +2 more sources

Role of astrocytes connexins - pannexins in acute brain injury

Neurotherapeutics
Acute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where some mechanisms show common determinants.
Juan E. Tichauer, Maximiliano Rovegno
doaj   +1 more source