Results 101 to 110 of about 7,055 (209)
Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization. [PDF]
, 2014 P2X7 receptors are nonselective cation channels gated by high extracellular ATP, but with sustained activation, receptor sensitization occurs, whereby the intrinsic pore dilates, making the cell permeable to large organic cations, which eventually leads ...
Adinolfi +61 more
core +3 more sources
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Metabolic reorganization and chronic inflammation are dynamic and diverse events in the tumor microenvironment (TME) that cause tumor propagation, spreading, and resistance to treatment. However, copper‐induced cell death (cuproptosis), which is a newly discovered form of regulated cell death (RCD) induced by high intracellular copper ions and is a ...
Yan Wang +6 more
wiley +1 more source
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more [PDF]
, 2015 Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from osteoblasts surrounded by bone matrix.
Plotkin, Lilian I., Stains, Joseph P.
core +1 more source
Mechanism of GSDMD in the Pathogenesis of Pasteurella multocida PmCQ2
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Pasteurella multocida serotype A (PmCQ2), a Gram‐negative zoonotic pathogen, causes severe respiratory disease in a variety of domestic and wild animals, leading to high morbidity and mortality and substantial agricultural economic losses. Pyroptosis, a gasdermin‐mediated programmed cell death mechanism, facilitates pathogen clearance but exacerbates ...
Qingqing Yang +8 more
wiley +1 more source
Probenecid, a gout remedy, inhibits pannexin 1 channels
American Journal of Physiology-Cell Physiology, 2008 Probenecid is a well-established drug for the treatment of gout and is thought to act on an organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking urate reuptake. Probenecid also has been shown to affect ATP release, leading to the suggestion that ATP release involves an organic anion transporter.
William, Silverman +2 more
openaire +3 more sources
Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes
Molecular Metabolism, 2015 Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the ...
Samantha E. Adamson +14 more
doaj +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang +17 more
wiley +1 more source
Roles of connexins and pannexins in (neuro)endocrine physiology. [PDF]
, 2015 International audienceTo ensure appropriate secretion in response to organismal demand, (neuro)endocrine tissues liberate massive quantities of hormone, which act to coordinate and synchronize biological signals in distant secretory and non-secretory ...
Desarménien, MG +3 more
core +5 more sources
Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease
Comprehensive Physiology, Volume 15, Issue 6, December 2025.The vascular endothelium is highly diverse, regulating permeability, vascular tone, repair, and inter‐organ communication. Endothelial heterogeneity supports tissue‐specific needs, but dysfunction drives cardiovascular disease. Transcriptomics, in vitro models, and redox signaling studies reveal therapeutic targets for precision treatment of ...
Anna E. Williams +6 more
wiley +1 more source
Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]
, 2018 Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw +11 more
core +1 more source