Results 171 to 180 of about 7,055 (209)

Noninvasive Focused Ultrasound as a Safe Modulator of Calcium-Dependent Neurochemical Signalling in Primary Cortical Cultures. [PDF]

Neurochem Res
Bano I, Jorratt P, Kútna V, Pala J, Tsenov G.   +4 more
europepmc   +1 more source

ACPA-Induced ATP release and K⁺ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis. [PDF]

Cell Commun Signal
Cai L, Zhang K, Gao J, Xiao B, Li M, Meng X, Chen Z, Chen X, Chen S, Li J.   +9 more
europepmc   +1 more source

Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate. [PDF]

Sci Rep
Hosoya M, Suda S, Ueno M, Shimanuki MN, Nishiyama T, Oishi N, Ozawa H.   +6 more
europepmc   +1 more source

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Intrapore lipids hydrophobically gate pannexin-1 channels

Science Signaling, 2022
Large-pore channels such as pannexin-1 (PANX1) typically lack pore-lining constriction points, leaving only speculations on how these channels functionally “close.” In this issue of Science Signaling , Kuzuya et al .
Connor L. Anderson, Roger J. Thompson
openaire   +2 more sources

Pannexin-1 channels in epilepsy

Neuroscience Letters, 2019
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino, Paige, Whyte-Fagundes, Georg, Zoidl, Peter L, Carlen   +3 more
openaire   +2 more sources

Regulation of Pannexin-1 channel activity

Biochemical Society Transactions, 2015
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been identified in platelets and shown to play roles in haemostasis and thrombosis.
Kirk A, Taylor, Joy R, Wright, Martyn P, Mahaut-Smith   +2 more
openaire   +2 more sources

Pannexin Channels: The Emerging Therapeutic Targets

Current Drug Targets, 2014
Intercellular communication plays a pivotal role in various physiological functions. This is mainly done through gap junctions and trans-membrane channels. The structural proteins forming these channels are different in vertebrates and invertebrates namely connexins and innexins respectively.
Misbahuddin, Mohammad, Hamed Said, Habib
openaire   +2 more sources

Pannexin 1 forms an anion-selective channel

Pflügers Archiv - European Journal of Physiology, 2012
Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-).
Ma, Weihong, Compan, Vincent, Zheng, Wenxuan, Martin, Elizabeth, North, R. Alan, Verkhratsky, Alexei, Surprenant, Annmarie   +6 more
openaire   +3 more sources