Results 181 to 190 of about 7,055 (209)
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Non-junction functions of pannexin-1 channels
Trends in Neurosciences, 2010Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic ...
Brian A, MacVicar, Roger J, Thompson
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Pannexin-1 Channel Regulates ATP Release in Epilepsy
Neurochemical Research, 2020With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However, the clinical outcome remains unsatisfactory due to the confounding symptoms and complications, as well as complex intrinsic pathogenesis. A better understanding of the pathogenesis of epilepsy should be able
Yisi, Shan, Yaohui, Ni, Zhiwei, Gao
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Cell-Cell Communication Beyond Connexins: The Pannexin Channels
Physiology, 2006Direct cell-to-cell communication through specialized intercellular channels is a characteristic feature of virtually all multi-cellular organisms. The remarkable functional conservation of cell-to-cell coupling throughout the animal kingdom, however, is not matched at the molecular level of the structural protein components.
Barbe, MT, Monyer, H, Bruzzone, R
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Channel activity of recombinant pannexin 1
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2011Mammalian taste cells of the type II release ATP, an afferent neurotransmitter, by employing unselective ATP-permeable ion channels. The molecular identity of these channels is not known with confidence, although evidence implicates certain channel proteins from the connexin and pannexin families as most likely candidates.
R. A. Romanov +3 more
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Pannexin channels and their links to human disease
Biochemical Journal, 2014In less than a decade, a small family of channel-forming glycoproteins, named pannexins, have captured the interest of many biologists, in large part due to their association with common diseases, ranging from cancers to neuropathies to infectious diseases.
Silvia, Penuela +3 more
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Gating Mechanism of ATP Release Pannexin Channels
202295 pages ; Pannexins (Panx1-3) are members of the emerging large-pore channel family. Their ubiquitous expression and ability to release small signaling molecules such as ATP has implicated pannexins in a host of critical cell signaling roles. However, the stimulus which impinges upon pannexin itself to reversibly open the channel gate remains elusive ...
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Channel plan: control of adaptive immune responses by pannexins
Trends in ImmunologyThe development of mammalian adaptive (i.e., B and T cell-mediated) immune responses is tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from the extracellular milieu are crucial regulators of adaptive immunity.
Igor Santiago-Carvalho +2 more
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CryoEM Structural Analysis of Pannexin 1 Channels
2018Pannexin 1 (Panx1) is a tetra-spanning, oligomeric, ubiquitously expressed, single membrane protein channel that mediates nucleotides such as ATP release upon activation. Panx1 channels are involved in diverse physiological and pathological processes such as blood pressure regulation, apoptotic cell clearance, inflammation, neurological ...
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Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
exaly
Anti-inflammatory pannexin 1 channel inhibitors
The present invention relates to single-domain antibodies directed to pannexin 1 (Panxl) and capable of inhibiting Panxl channel activity. The single-domain antibodies can be used to treat or diagnose inflammation.Vinken, Mathieu +3 more
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