Results 11 to 20 of about 7,055 (209)
Pannexin 1 channels in skeletal muscles [PDF]
Frontiers in Physiology, 2014 Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea +6 more
doaj +5 more sources
Connexin and pannexin (hemi)channels in the liver [PDF]
Frontiers in Physiology, 2014 The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbour connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43.
Michaël eMaes +11 more
doaj +6 more sources
Pharmacology of pannexin channels. [PDF]
Curr Opin Pharmacol, 2023 Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Koval M, Schug WJ, Isakson BE.
europepmc +3 more sources
Connexin and pannexin channels in cancer. [PDF]
BMC Cell Biol, 2016 Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and ...
Jiang JX, Penuela S.
europepmc +6 more sources
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation [PDF]
Molecular & Cellular Oncology, 2019 Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined.
Benjamin Demarco +2 more
doaj +4 more sources
Pannexin channels in the kidney. [PDF]
Am J Physiol Renal PhysiolRenal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD +5 more
europepmc +2 more sources
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
PLoS Biology, 2022 Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear.
Flora Vasile +10 more
doaj +2 more sources
Pannexin-1 Channels as Mediators of Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 Neuroinflammation is a major component of central nervous system (CNS) injuries and neurological diseases, including Alzheimer’s disease, multiple sclerosis, neuropathic pain, and brain trauma. The activation of innate immune cells at the damage site causes the release of pro-inflammatory cytokines and chemokines, which alter the functionality of ...
Seo, Joon Ho +2 more
openaire +4 more sources
Nature Communications, 2022 Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.
Amanda C. Filiberto +13 more
doaj +1 more source
Inhibitors of connexin and pannexin channels as potential therapeutics. [PDF]
Pharmacol Ther, 2017 While gap junctions support the exchange of a number of molecules between neighboring cells, connexin hemichannels provide communication between the cytosol and the extracellular environment of an individual cell. The latter equally holds true for channels composed of pannexin proteins, which display an architecture reminiscent of connexin hemichannels.
Willebrords J +3 more
europepmc +5 more sources