Results 21 to 30 of about 7,055 (209)

Pannexin channels are not gap junction hemichannels. [PDF]

Channels (Austin), 2011
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Sosinsky GE, Boassa D, Dermietzel R, Duffy HS, Laird DW, MacVicar B, Naus CC, Penuela S, Scemes E, Spray DC, Thompson RJ, Zhao HB, Dahl G.   +12 more
europepmc   +4 more sources

Unexpected link between an antibiotic, pannexin channels and apoptosis. [PDF]

Nature, 2014
Plasma membrane pannexin 1 channels (PANX1) release nucleotide find-me signals from apoptotic cells to attract phagocytes. Here we show that the quinolone antibiotic trovafloxacin is a novel PANX1 inhibitor, by using a small-molecule screen. Although quinolones are widely used to treat bacterial infections, some quinolones have unexplained side effects,
Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS.   +6 more
europepmc   +4 more sources

The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation [PDF]

, 2013
Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second ...
A MacKenzie, A Surprenant, AN Shemon, B Gu, BC Suh, BJ Gu, BJ Gu, BM Saunders, BS Khakh, BS Khakh, C Andrei, C Marques-da-Silva, C Sun, C Virginio, Chengqun Sun, CP Lai, D Leon, D Zink, DS Emmett, DS Samways, E Adinolfi, E Bulanova, F Bretschneider, F Rassendren, G Girolomoni, H Gunosewoyo, HJ Bradley, HM Costa-Junior, HZ Hu, JS Wiley, K Schroder, KA Hillman, L Gudipaty, L Stokes, LC Denlinger, LC Denlinger, LE Browne, LH Jiang, LH Jiang, M Li, M Li, Michelle E. Heid, ML Gavala, ML Smart, MT Miras-Portugal, P Marin-Garcia, P Pelegrin, P Pelegrin, Peter A. Keyel, Pierre Bobé, Q Li, R Sluyter, RA North, Russell D. Salter, S Chaumont, S Kracun, S Locovei, S Penuela, S Roger, SD Ohlendorff, SD Silberberg, SL Fernando, SL Fernando, T Kawate, T Sugiyama, TM Egan, V Petrilli, W Duckwitz, Y Shinozaki   +68 more
core   +7 more sources

S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]

Journal of Biological Chemistry, 2012
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Alexander W, Lohman, Janelle L, Weaver, Marie, Billaud, Joanna K, Sandilos, Rachael, Griffiths, Adam C, Straub, Silvia, Penuela, Norbert, Leitinger, Dale W, Laird, Douglas A, Bayliss, Brant E, Isakson   +10 more
openaire   +2 more sources

Connexin communication compartments and wound repair in epithelial tissue [PDF]

, 2018
Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they ...
Chanson, Marc, Martin, Patricia E., O'Shaughnessy, Erin M., Watanabe, Masakatsu, Zoso, Alice   +4 more
core   +8 more sources

Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft. [PDF]

PLoS Biology, 2014
Neuronal computations strongly depend on inhibitory interactions. One such example occurs at the first retinal synapse, where horizontal cells inhibit photoreceptors.
Rozan Vroman, Lauw J Klaassen, Marcus H C Howlett, Valentina Cenedese, Jan Klooster, Trijntje Sjoerdsma, Maarten Kamermans   +6 more
doaj   +1 more source

Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury

Biomedicines, 2022
Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or ...
Alice McDouall, Kelly Q. Zhou, Laura Bennet, Colin R. Green, Alistair J. Gunn, Joanne O. Davidson   +5 more
doaj   +1 more source

Connexins, pannexins, innexins: novel roles of "hemi-channels” [PDF]

Pflügers Archiv - European Journal of Physiology, 2018
The advent of multicellular organisms, some 800 million years ago, necessitated the development of mechanisms for cell-to-cell synchronization and for the spread of signals across increasingly large cell populations [168, 185]. Many structures and mechanisms have evolved to achieve such functions [4, 15].
Meda, Paolo, Scemes, Eliana, Spray, David   +2 more
core   +5 more sources

Pannexin 3 channels in health and disease

Purinergic Signalling, 2021
Pannexin 3 (PANX3) is a member of the pannexin family of single membrane channel-forming glycoproteins. Originally thought to have a limited localization in cartilage, bone, and skin, PANX3 has now been detected in a variety of other tissues including skeletal muscle, mammary glands, the male reproductive tract, the cochlea, blood vessels, small ...
Brooke L. O’Donnell, Silvia Penuela
openaire   +3 more sources

Innexin and pannexin channels and their signaling [PDF]

FEBS Letters, 2014
Innexins are bifunctional membrane proteins in invertebrates, forming gap junctions as well as non‐junctional membrane channels (innexons). Their vertebrate analogues, the pannexins, have not only lost the ability to form gap junctions but are also prevented from it by glycosylation.
Dahl, Gerhard, Muller, Kenneth J.
openaire   +2 more sources