Results 31 to 40 of about 7,055 (209)
Mind the gap: connexins and pannexins in platelet function
Platelets, 2021 Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Kirk a Taylor +2 more
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Communications Biology, 2022 The Panx1a and Panx1b (pannexin) ATP release channels exhibit pro- and anti-convulsant effects, respectively, in a zebrafish model, providing further insight into the role of pannexins in seizure development.
Paige Whyte-Fagundes +6 more
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A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]
, 2019 Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Buratto, Damiano +12 more
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An overview of the focus of the International Gap Junction Conference 2017 and Future Perspectives [PDF]
, 2018 n/
Kwak, Brenda R., Martin, Patricia E.
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Pannexin channels and ischaemia [PDF]
The Journal of Physiology, 2014 AbstractAn ischaemic stroke occurs during loss of blood flow in the brain from the occlusion of a blood vessel. The ischaemia itself comprises a complex array of insults, including oxygen and glucose deprivation (OGD), glutamate excitotoxicity, acidification/hypercapnia, and loss of sheer forces.
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Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation
Neural Development, 2012 Background Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in ...
Wicki-Stordeur Leigh E +4 more
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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]
, 2009 Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Mohamed Lamkanfi +43 more
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Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases [PDF]
The Journal of Membrane Biology, 2016 Cellular and molecular mechanisms of wound healing, tissue repair, and fibrogenesis are established in different organs and are essential for the maintenance of function and tissue integrity after cell injury. These mechanisms are also involved in a plethora of fibroproliferative diseases or organ-specific fibrotic disorders, all of which are ...
Bruno Cogliati +9 more
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Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves
Frontiers in Cellular Neuroscience, 2017 The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton +10 more
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ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
eLife, 2021 Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and pathophysiological processes via its ability to support release of ATP and other cellular metabolites for local intercellular signaling. However, to date, there has been no
Adishesh K Narahari +14 more
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