Results 51 to 60 of about 7,055 (209)
Circulating levels of ATP is a biomarker of HIV cognitive impairment
EBioMedicine, 2020 Background: In developed countries, Human Immunodeficiency Virus type-1 (HIV-1) infection has become a chronic disease despite the positive effects of anti-retroviral therapies (ART), but still at least half of the HIV infected population shown signs of ...
Stephani Velasquez +7 more
doaj +1 more source
Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex [PDF]
, 1922 The purinergic receptor P2X7 is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X7 receptors in vivo are non-selective cation channels or form large pores
Locovei, Silviu +4 more
core +2 more sources
Oligomeric State of a Pannexin Channel [PDF]
Biophysical Journal, 2013 Pannexins are a recently-discovered family of integral membrane proteins in vertebrates that form non-selective homomeric or heteromeric pores in the plasma membrane. These channels seem important in ATP signaling in the central nervous system and the immune response, as well as in ischemic and apoptotic cell death, yet their mechanism remains unknown.
Kumpf, Julia M., Kawate, Toshimitsu
openaire +1 more source
The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis
Cells, 2022 The human immunodeficiency virus-1 (HIV) enters the brain shortly after infection, leading to long-term neurological complications in half of the HIV-infected population, even in the current anti-retroviral therapy (ART) era. Despite decades of research,
Cristian A. Hernandez, Eugenin Eliseo
doaj +1 more source
GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]
, 2008 The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
core +1 more source
Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory [PDF]
, 2016 Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Albertini, Giulia +5 more
core +2 more sources
Pannexin membrane channels are mechanosensitive conduits for ATP [PDF]
FEBS Letters, 2004 Intercellular calcium wave propagation initiated by mechanical stress is a phenomenon found in nearly all cell types. The waves utilize two pathways: transfer of InsP3 directly from cell to cell through gap junction channels and release of ATP onto extracellular purinergic receptors.
Bao, Li, Locovei, Silviu, Dahl, Gerhard
openaire +2 more sources
Frontiers in Physiology, 2022 According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface.
Sadao Ohyama +17 more
doaj +1 more source
Reversal of loss of bone mass in old mice treated with mefloquine [PDF]
, 2018 Aging is accompanied by imbalanced bone remodeling, elevated osteocyte apoptosis, and decreased bone mass and mechanical properties; and improved pharmacologic approaches to counteract bone deterioration with aging are needed.
Allen, Matthew R. +8 more
core +1 more source
Connexins and pannexins in liver damage [PDF]
, 2016 Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes.
Cogliati, Bruno +7 more
core +1 more source