Results 61 to 70 of about 7,055 (209)
Intrinsic properties and regulation of Pannexin 1 channel [PDF]
Channels, 2014 Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, ionotropic and metabotropic receptor signaling, and via ...
Yu-Hsin, Chiu +2 more
openaire +2 more sources
Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
Frontiers in Immunology, 2020 The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu +5 more
doaj +1 more source
Cancer Science, EarlyView.Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda +2 more
wiley +1 more source
Regulation of pannexin channels by post‐translational modifications
FEBS Letters, 2014 The large‐pore channels formed by the pannexin family of proteins have been implicated in many physiological and pathophysiological functions, mainly through their ATP release function. However, a tight regulation of channel opening is necessary to modulate their function in vivo.
Penuela, Silvia +2 more
openaire +2 more sources
A review of the current state of pannexin channels as they relate to the blood vessel wall
Journal of Medical Sciences, 2017 Pannexin proteins comprise a family of channels whose sole function, to date, is the release of nucleotides (e.g., adenosine 5'-triphosphate [ATP] and uridine 5′-triphosphate [UTP]).
Brant E Isakson
doaj +1 more source
Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly
eLife, 2023 Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries.
Hirohide Takahashi +4 more
doaj +1 more source
Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways [PDF]
, 2013 Lubricin is a secreted proteoglycan encoded by the Prg4 locus that is abundantly expressed by superficial zone articular chondrocytes and has been noted to both be sensitive to mechanical loading and protect against the development of osteoarthritis.
Grodzinsky, Alan J. +4 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm +3 more
wiley +1 more source
Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice
eLife, 2021 Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown.
Zdravka Daneva +10 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Yoshiaki Furusawa +9 more
wiley +1 more source