Results 151 to 160 of about 2,639 (160)
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Sleep-wake cycle and experimental models of Panx1 mutations
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018To test the hypothesis of a possible role of the Panx1 (pannexin-1) mutation in changing the sleep - wake cycle.Continuous 24 h recording of the EEG and movement activity in Panx1 knockout and wild type mice was performed.A significant increase in wake percentage at the expense of a decrease in slow-wave sleep was found in knockout mice as compared to ...
V M, Kovalzon +3 more
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Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids
2023AbstractDysfunctional paracrine signaling through Pannexin 1 (PANX1) channels is linked to several adult neurological pathologies and emerging evidence suggests that PANX1 plays an important role in human brain development. It remains unclear how early PANX1 influences brain development, or how loss of PANX1 alters the developing human brain.
Rebecca J. Noort +4 more
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A novel heterozygous variant in PANX1 causes primary infertility due to oocyte death
Journal of Assisted Reproduction and Genetics, 2022Variants in the pannexin1 (PANX1) gene have been reported to be associated with oocyte death and recurrent in vitro fertilization failure. In this study, we performed genetic analysis in the patient with female infertility due to oocyte death to identify the disease-causing gene variant in the patient.We characterized one patient from a non ...
Juepu Zhou +5 more
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[Distribution and regulation of Panx1 protein].
Sheng li ke xue jin zhan [Progress in physiology], 2014Pannexin1 (Panx1) is a subtype of the newly discovered gap junction proteins named Pannexin(s). Panx1 is widely expressed in the nervous system, cardiovascular system, etc and can form non-selective and large conductance hemichannel. It has been demonstrated that various conditions can regulate Panx1 open and affect the body's physiological function ...
Xiang-Xing, Kong +3 more
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Destination and consequences of Panx1 and mutant expression in polarized MDCK cells
Experimental Cell Research, 2019The channel-forming membrane glycoprotein pannexin 1 (Panx1) is best characterized as an ATP release channel. To investigate the trafficking and sorting of Panx1, we used polarized MDCK cells and non-polarized BICR-M1Rk cells to track the fate of GFP-tagged Panx1.
Michelle G, Shum +3 more
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Panx1 as a potential therapeutic target for cardiac ischemia/reperfusion injury
2022Cardiovascular disease (CVD) is recognized as a major cause of death worldwide. Restriction of the blood supply leads to detrimental effects within the myocardium, which are paradoxically exacerbated upon reperfusion. Few therapeutic strategies are available up to date, yet none of the treatment is efficient enough to abolish ischemia/reperfusion (I/R)
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Conformational rearrangements associated with Panx1 channel gating
Biophysical Journal, 2023Jacqueline J. Ehrlich +2 more
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Divalent cations promote Panx1 channel activity through its C-terminal domain
Biophysical Journal, 2022Erik K. Henze, Toshimitsu Kawate
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PANX1 and PANX3: opposing effects on cancer cell properties
The Journal of PhysiologySheina Franco, Liljana Skakavac
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PANX1 in Diabetic Cardiomyopathy: Molecular Mechanisms (Abstract ID: 171608)
The Journal of Pharmacology and Experimental TherapeuticsSherif SB. Bahriz +6 more
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