Results 11 to 20 of about 111,709 (349)

Potential inhibitors against papain-like protease of novel coronavirus (SARS-CoV-2) from FDA approved drugs

, 2020
The cases of 2019 novel coronavirus (SARS-CoV-2) infection have been continuously increasing ever since its outbreak in China last December. Currently, there are no approved drugs to treat the infection.
Rimanshee Arya
semanticscholar   +2 more sources

Semi-Solid Pharmaceutical Formulations for the Delivery of Papain Nanoparticles [PDF]

Pharmaceutics, 2020
Papain is a therapeutic enzyme with restricted applications due to associated allergenic reactions. Papain nanoparticles have shown to be safe for biomedical use, although a method for proper drug loading and release remains to be developed.
Caroline S. A. de Lima, Justine P. R. O. Varca, Kamila M. Nogueira, Gabriela N. Fazolin, Lucas F. de Freitas, Eliseu W. de Souza, Ademar B. Lugão, Gustavo. H. C. Varca   +7 more
doaj   +2 more sources

The Effect of Papain Enzyme Dosage on the Modification of Egg-yolk Lecithin Emulsifier Product through Enzymatic Hydrolysis Reaction

, 2018
Lecithin is needed as a bioemulsifier product in stabilizing agents for the food, pharmaceutical and cosmetic industries due to its renewability and as it is environmentally friendly.
Setiadi Setiadi, N. Hidayah
semanticscholar   +3 more sources

Proteolytic and structural mechanisms in tuna tenderization by papain, bromelain and ficin. [PDF]

Food Chem X
Wang ZY, Ma YZ, Jiang XY, Wang CY, Li YQ, Liang Y, Ren XD, Qin LC, Zhao XZ.   +8 more
europepmc   +2 more sources

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

EMBO Journal, 2020
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein, but also removes ubiquitin‐like ISG15 protein modifications as well as ...
T. Klemm, G. Ebert, D. Calleja, C. Allison, L. Richardson, Jonathan P. Bernardini, Bernadine G. C. Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Z. Gan, James P. Cooney, Marcel Doerflinger, A. E. Au, T. Blackmore, Gerbrand J. van der Heden van Noort, P. Geurink, H. Ovaa, J. Newman, A. Riboldi-Tunnicliffe, P. Czabotar, Jeffrey P. Mitchell, R. Feltham, B. C. Lechtenberg, K. Lowes, G. Dewson, M. Pellegrini, G. Lessene, D. Komander   +28 more
semanticscholar   +1 more source

SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition

ChemBioChem, 2022
Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline the importance of investigating various viral proteins as potential drug targets.
S. Ullrich, Christoph Nitsche
semanticscholar   +1 more source

Biochemical Properties and Anti-Biofilm Activity of Chitosan-Immobilized Papain

Marine Drugs, 2021
Chitosan, the product of chitin deacetylation, is an excellent candidate for enzyme immobilization purposes. Here we demonstrate that papain, an endolytic cysteine protease (EC: 3.4.22.2) from Carica papaya latex immobilized on the matrixes of medium ...
D. Baidamshina, V. Koroleva, S. Olshannikova, E. Trizna, M. Bogachev, V. Artyukhov, M. Holyavka, A. Kayumov   +7 more
semanticscholar   +1 more source

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Science Advances, 2020
A multidisciplinary approach yields novel inhibitors and reveals substrate specificity, structure, and mechanisms of CoV-2 PLpro. Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising target ...
Wioletta Rut, Z. Lv, Mikołaj Żmudziński, Stephanie Patchett, D. Nayak, S. Snipas, Farid El Oualid, Tony T. Huang, M. Békés, M. Drąg, S. Olsen   +10 more
semanticscholar   +1 more source

In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking, ADMET, Toxicity and DFT Studies

Molecules, 2021
Papain-like protease is an essential enzyme in the proteolytic processing required for the replication of SARS-CoV-2. Accordingly, such an enzyme is an important target for the development of anti-SARS-CoV-2 agents which may reduce the mortality ...
Mohamed S. Alesawy, E. Elkaeed, Aisha A. Alsfouk, A. Metwaly, I. Eissa   +4 more
semanticscholar   +1 more source

Development and clinical application of hydrogel formulations containing papain and urea for wound healing [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2023
Hydrogels are used for wound treatment, as they may contain one or more active components and protect the wound bed. Papain is one of the active substances that have been used with this purpose, alongside urea.
Thais Menezes dos Santos, Danieli Silva Feijó de Sousa, Karina Chamma Di Piero, Adriane Regina Todeschini, Wagner Barbosa Dias, Catarina Amorim Oliveira, Elisabete Pereira dos Santos, Mariana Sato de Souza Bustamante Monteiro, Maria Kátia Gomes, Cristiano dos Reis Moura, Pedro Antônio Castelo Teixeira, Eduardo Ricci-Junior, Zaida Maria Faria de Freitas   +12 more
doaj   +1 more source