Results 21 to 30 of about 111,709 (349)

Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease

open access: yesACS Infectious Diseases, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The outbreak currently includes over 3.7 million cases and 260,000 fatalities.
Brendan T. Freitas   +8 more
semanticscholar   +1 more source

Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation

open access: yesInternational Journal of Molecular Sciences, 2021
Papain is a proteolytic enzyme present in the leaves, fruits, roots, and latex of the Carica papaya (papaya) plant. Although it exhibits a wide range of activities, there are no reports on the anti-obesity effects of papain.
Yun-Mi Kang   +4 more
semanticscholar   +1 more source

Evidence of β-sheet structure induced kinetic stability of papain upon thermal and sodium dodecyl sulphate denaturation [PDF]

open access: yesJournal of the Serbian Chemical Society, 2015
Papain is a protease that consists of α-helical and β-sheet domains which unfold almost independently. Both, papain considerable thermal stability and sodium dodecyl sulphate (SDS) resistance have been shown.
Rašković Brankica   +3 more
doaj   +1 more source

IMMOBILIZATION OF PAPAIN ON CHITOSAN

open access: yesIndonesian Journal of Chemistry, 2010
In this study, papain was immobilized on chitosan with Mg(II) cosslinked agent. Studies on free and immobilized papain systems for determination of optimum pH, optimum temperatur, thermal stability and reusability were carried out.
Sari Edi Cahyaningrum   +3 more
doaj   +1 more source

Hybridization of papain molecules and DNA-wrapped single-walled carbon nanotubes evaluated by atomic force microscopy in fluids

open access: yesScientific Reports, 2023
Although various conjugates of single-walled carbon nanotubes (SWNTs) and biomolecules, such as nanobiosensors and nanobiodevices, have been reported, the conjugation of papain and SWNTs have not been reported because of the formation of unexpected ...
Masaki Kitamura, Kazuo Umemura
doaj   +1 more source

Chemical septoplasty using papain enzyme—a feasibility study

open access: yesThe Egyptian Journal of Otolaryngology, 2021
Background Though surgery can correct nasal septal defects through a procedure called septoplasty, many people seek non-surgical options. Papain enzyme has been used in the past to lyse intervertebral disc and has shown to have a lytic effect on ...
Arun Angelo Patil   +3 more
doaj   +1 more source

Utilizing osteocyte derived factors to enhance cell viability and osteogenic matrix deposition within IPN hydrogels [PDF]

open access: yes, 2020
Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly ...
Hoey, David A.   +2 more
core   +1 more source

Optimization of macromolecular prodrugs of the antitumor antibiotic adriamycin [PDF]

open access: yes, 1985
In our earlier work [10] on aminoribosyl-bound prodrugs of adriamycin (ADR) using poly(α-l-glutamic acid) (PGA) grafted in high yield (90–100 mol.%) with various peptide spacers as a plasma-soluble macromolecular carrier we observed rather low cytotoxic ...
Feijen, J.   +6 more
core   +2 more sources

Improving Tensile Bond Strength of Orthodontic Bracket by Applying Papain Gel as an Email Deproteinization Agent

open access: yesJournal of Dentistry Indonesia, 2017
An effort to improve the bonding between bracket and tooth surface is required. Objective: The aim of this studywas to evaluate the effect of papain gel on tensile bond strength (TBS) and adhesive remnant index (ARI) of the orthodontic brackets. Methods:
Niswati Fathmah Rosyida   +2 more
doaj   +1 more source

In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris [PDF]

open access: yes, 2006
We examined the mechanism of action and compared the anthelmintic efficacy of cysteine proteinases from papaya, pineapple, fig, kiwi fruit and Egyptian milkweed in vitro using the rodent gastrointestinal nematode Heligmosomoides polygyrus.
Behnke, J.M.   +4 more
core   +3 more sources

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