Results 91 to 100 of about 666,834 (274)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

The impact of pathogenic and artificial mutations on Claudin-5 selectivity from molecular dynamics simulations

Computational and Structural Biotechnology Journal, 2023
Tight-junctions (TJs) are multi-protein complexes between adjacent endothelial or epithelial cells. In the blood-brain-barrier (BBB), they seal the paracellular space and the Claudin-5 (Cldn5) protein forms their backbone. Despite the fundamental role in
Alessandro Berselli, Giulio Alberini, Fabio Benfenati, Luca Maragliano   +3 more
doaj   +1 more source

Current and evolving approaches for improving the oral permeability of BCS Class III or analogous molecules [PDF]

, 2016
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability ...
Dave, Vivek S, Gupta, Deepak, Gupta, Sheeba Varghese, Nguyen, Phong, Yu, Monica   +4 more
core   +2 more sources

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells

bioRxiv, 2019
Tissue acidosis can be a consequence of numerous disease states including stroke, myocardial infarction, limb ischemia, and inflammation. Blood vessels existing in the affected tissues are associated with the progression of acidosis-related diseases ...
Elizabeth A. Krewson, E. Sanderlin, M. Marie, J. Velcicky, P. Loetscher, Li V. Yang   +5 more
semanticscholar   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

An industrial procedure for the intestinal permeability enhancement of acyclovir: in-vitro and histological evidence

Scientific Reports, 2023
Acyclovir, an antiviral drug, has low bioavailability due to its low permeability. Consequently, high drug doses and frequent administration are required.
Omar Y. Mady, Sara Mohsen Thabit, Suzan E. Abo Elnasr, Asmaa A. Hedaya   +3 more
doaj   +1 more source

Developmental expression of claudins in the mammary gland [PDF]

, 2017
Claudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N ...
Baumgartner, Heidi K., Bitler, Benjamin G., Burns, Valerie, Kobayashi, Ken, Neville, Margaret C., Ramanathan, Palaniappian, Rudolph, Michael C., Stein, Torsten, Webb, Patricia   +8 more
core   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research, EarlyView.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
wiley   +1 more source

Brush border membrane vesicle and Caco-2 cell line: Two experimental models for evaluation of absorption enhancing effects of saponins, bile salts, and some synthetic surfactants

Journal of Advanced Pharmaceutical Technology & Research, 2016
The aim of this study was to investigate the influence of absorption enhancers in the uptake of hydrophilic compounds. The permeation of the two hydrophilic drug models gentamicin and 5 (6)-carboxyfluorescein (CF) across the brush border membrane ...
Eskandar Moghimipour, Sayyed Abolghassem Sajadi Tabassi, Mohammad Ramezani, Somayeh Handali, Raimar Lobenberg   +4 more
doaj   +1 more source

The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

Frontiers in Nutrition, 2021
An increased intestinal permeability has been described in various gastrointestinal and non-gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability is relatively broad and includes not only an altered paracellular ...
Tim Vanuytsel, Tim Vanuytsel, Jan Tack, Jan Tack, Ricard Farre   +4 more
doaj   +1 more source