Results 181 to 190 of about 41,666 (255)

Anaerobe‐Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Genital microbiome dysbiosis is an important risk factor for the sexual acquisition of human immunodeficiency virus (HIV) in both the male and female genital tracts. The vaginal, penile and urethral mucosae are distinct microenvironments with characteristic microbiome compositions.
Shirley Constable, Yasamin Minazadeh, Lane B. Buchanan, Henryroger Ssemunywa, Ronald M. Galiwango, Rupert Kaul, Jessica L. Prodger   +6 more
wiley   +1 more source

Aging disrupts blood-brain and blood-spinal cord barrier homeostasis, but does not increase paracellular permeability. [PDF]

Geroscience
Cummins MJ, Cresswell ET, Bevege RJ, Smith DW.   +3 more
europepmc   +1 more source

Beyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2 [PDF]

, 2013
Gehwolf, R., Krizbai, István Adorján, Toepfer, S., Traweger, A., Wagner, R.N., Wilhelm, Imola, Zweimueller-Mayer, J.   +6 more
core   +1 more source

Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness

Genes to Cells, Volume 31, Issue 3, May 2026.
COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon, An‐Na Bae, Hajin Lee, Keon Uk Park, Hyun Mu Shin, Jong Ho Park, Kwang Seok Kim, In‐Chul Park, Yun‐Han Lee   +8 more
wiley   +1 more source

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

Functionalization of Silica Nanoparticles for Tailored Interactions with Intestinal Cells and Chemical Modulation of Paracellular Permeability. [PDF]

Small Sci
Iriarte-Mesa C, Bergen J, Danielyan K, Crudo F, Marko D, Kählig H, Del Favero G, Kleitz F.   +7 more
europepmc   +1 more source

Neural network surrogates enable robust and accessible modeling of renal epithelial transport

Physiological Reports, Volume 14, Issue 10, May 2026.
This study introduces a neural network–based surrogate that replaces fragile numerical solvers in mechanistic models of renal epithelial transport. By learning steady‐state solutions from high‐fidelity simulations, the approach delivers fast, robust predictions across physiological conditions, including transporter inhibition, while avoiding ...
Anita T. Layton
wiley   +1 more source

Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn's Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability. [PDF]

J Crohns Colitis, 2020
Keita ÅV, Alkaissi LY, Holm EB, Heil SDS, Chassaing B, Darfeuille-Michaud A, McKay DM, Söderholm JD.   +7 more
europepmc   +1 more source

Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche. [PDF]

Clin Sci (Lond)
Salem S, Leach L.
europepmc   +1 more source

Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability. [PDF]

Acta Pharmacol Sin
Zhang XL, Du WH, Qian SX, Lu XD, Yu X, Fang HL, Dong JL, Song M, Sun YY, Wu XQ, Shen YF, Hao YN, Shen MH, Zhou BQ, Wang YP, Xu CY, Jin XC.   +16 more
europepmc   +1 more source