Results 11 to 20 of about 10,332 (185)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. [PDF]

Springerplus, 2016
Zyoud SH, Waring WS, Al-Jabi SW, Sweileh WM, Awang R.   +4 more
europepmc   +2 more sources

Comparative evaluation of the effectiveness and safety of 12-hour and 21-hour protocols for the administration of acetylcysteine in paracetamol poisoning

Вестник анестезиологии и реаниматологии, 2023
Background. Acetylcysteine (ACC) is an effective antidote for paracetamol poisoning. There are various schemes for its application. At the same time, there is currently no information about the most priority of them in this pathology.
A. Yu. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, V. V. Kulabukhov, L. R. Asanova   +5 more
doaj   +1 more source

Acute paracetamol poisonings received at the Oran University Hospital

Toxicology Reports, 2020
Introduction: Paracetamol is the most commonly used drug worldwide for its analgesic/antipyretic effect and especially a non-prescription access in pharmacies.
Bilel Chefirat, Anissa Zergui, Chaïmaa Rahmani, Meriem Nour Belmessabih, Haciba Rezk-kallah   +4 more
doaj   +1 more source

Successful management of delayed presentation of massive paracetamol overdose in a resource‐limited setting: A case report from Nepal

Clinical Case Reports, 2022
We present a case of self‐poisoning with a massive dose of paracetamol by a young Nepalese female patient who presented late to our emergency department.
Pratik Lamichhane, Kailash Mani Pokhrel, Bijay Bhandari, Anushka Agrawal, Bhumika Ghimire, Olita Shilpakar   +5 more
doaj   +1 more source

Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). [PDF]

BMC Pharmacol Toxicol, 2013
BACKGROUND: Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged.
Thanacoody HK, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SH, Bateman DN.   +9 more
europepmc   +3 more sources

Adverse effects of paracetamol

Journal of Education, Health and Sport, 2017
Admission. Paracetamol (acetaminophen) is one of the most popular medicinal substances in the world, characterized by analgesic and antipyretic properties. This pharmacy is issued without a prescription and can be purchased not only in pharmacies.
Michał Konopelko, Aneta Szafraniec, Dominik Porada, Małgorzata Pucułek, Daria Przybylska   +4 more
doaj   +3 more sources

Case report: Possible acetaminophen poisoning complicated by puerperal sepsis

South Sudan Medical Journal, 2021
Acetaminophen (paracetamol) toxicity is an important cause of morbidity and mortality worldwide. It is estimated that poisoning contributes to more than 1 million poisonings and up to half a million deaths each year, yet it is preventable and treatable ...
Arop M. D. Kual
doaj   +1 more source

Delayed presentation of paracetamol overdose

African Journal of Emergency Medicine, 2020
Introduction: Deliberate self-harm, including intentional self-poisoning, remains a major health concern in South Africa. Increasing number of cases place a significant burden on our Emergency Centres (EC's).
Johnre Retief Els, Luan Taljaard, Bruce Strover   +2 more
doaj   +1 more source

Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning.

PLoS Medicine, 2007
BackgroundParacetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States. Successful interventions to reduced harm from paracetamol poisoning are needed.
Oliver W Morgan, Clare Griffiths, Azeem Majeed   +2 more
doaj   +1 more source