Results 11 to 20 of about 3,952 (160)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Acute Paracetamol Poisoning [PDF]

BMJ, 1970
Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of hepatocellular damage. Liver damage is a toxic effect which is present in most patients who ingest more than 15 g. of paracetamol.
A T, Proudfoot, N, Wright
openaire   +2 more sources

Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America

Toxicology Reports, 2022
Paracetamol, also known as acetaminophen (N-acetyl-para-aminophenol, APAP) is the world’s most used over-the-counter analgesic-antipyretic drug. Despite its good safety profile, acetaminophen can cause severe hepatotoxicity in overdose, and poisoning ...
Samuel James Offor, Cecilia Nwadiuto Amadi, Ifeyinwa Chijioke-Nwauche, Jose E. Manautou, Orish E. Orisakwe   +4 more
doaj   +1 more source

Acute paracetamol poisonings received at the Oran University Hospital

Toxicology Reports, 2020
Introduction: Paracetamol is the most commonly used drug worldwide for its analgesic/antipyretic effect and especially a non-prescription access in pharmacies.
Bilel Chefirat, Anissa Zergui, Chaïmaa Rahmani, Meriem Nour Belmessabih, Haciba Rezk-kallah   +4 more
doaj   +1 more source

Comparative evaluation of the effectiveness and safety of 12-hour and 21-hour protocols for the administration of acetylcysteine in paracetamol poisoning

Вестник анестезиологии и реаниматологии, 2023
Background. Acetylcysteine (ACC) is an effective antidote for paracetamol poisoning. There are various schemes for its application. At the same time, there is currently no information about the most priority of them in this pathology.
A. Yu. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, V. V. Kulabukhov, L. R. Asanova   +5 more
doaj   +1 more source

Successful management of delayed presentation of massive paracetamol overdose in a resource‐limited setting: A case report from Nepal

Clinical Case Reports, 2022
We present a case of self‐poisoning with a massive dose of paracetamol by a young Nepalese female patient who presented late to our emergency department.
Pratik Lamichhane, Kailash Mani Pokhrel, Bijay Bhandari, Anushka Agrawal, Bhumika Ghimire, Olita Shilpakar   +5 more
doaj   +1 more source

Paracetamol poisoning and the kidney [PDF]

Journal of Clinical Pharmacy and Therapeutics, 1993
Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis of animal work, may actually potentiate tubular damage.
A F, Jones, J A, Vale
openaire   +2 more sources

Adverse effects of paracetamol

Journal of Education, Health and Sport, 2017
Admission. Paracetamol (acetaminophen) is one of the most popular medicinal substances in the world, characterized by analgesic and antipyretic properties. This pharmacy is issued without a prescription and can be purchased not only in pharmacies.
Michał Konopelko, Aneta Szafraniec, Dominik Porada, Małgorzata Pucułek, Daria Przybylska   +4 more
doaj   +3 more sources

Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning.

PLoS Medicine, 2007
BackgroundParacetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States. Successful interventions to reduced harm from paracetamol poisoning are needed.
Oliver W Morgan, Clare Griffiths, Azeem Majeed   +2 more
doaj   +1 more source

Delayed presentation of paracetamol overdose

African Journal of Emergency Medicine, 2020
Introduction: Deliberate self-harm, including intentional self-poisoning, remains a major health concern in South Africa. Increasing number of cases place a significant burden on our Emergency Centres (EC's).
Johnre Retief Els, Luan Taljaard, Bruce Strover   +2 more
doaj   +1 more source