Results 51 to 60 of about 3,159,185 (350)

A new paradigm for classifying and treating HER2‐positive breast cancer

Cancer Reports, 2023
Background Because of the phenomenal success of treatment with monoclonal antibodies and antibody‐drug conjugates targeting human epidermal growth factor receptor 2 (HER2), most patients with early‐stage HER2‐positive breast cancer (HER2+ BC) and some ...
Xuexin He, Sai‐Ching J. Yeung, Francisco J. Esteva   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Questioning the rise of gelatinous zooplankton in the World's oceans [PDF]

, 2012
During the past several decades, high numbers of gelatinous zooplankton species have been reported in many estuarine and coastal ecosystems. Coupled with media-driven public perception, a paradigm has evolved in which the global ocean ecosystems are ...
Acuña, Alenka Malej, Atkinson, Beaglehole, Brodeur, Brodeur, Butterfield, Carlos M. Duarte, Cathy H. Lucas, Chen, Claudia E. Mills, Condon, Condon, Costello, Dakin, Daly, Daryanabard, Dawson, Dong, Ducklow, Edwards, Eiane, Gaillard, Galigher, Gand, Gorokhova, Goy, Graham, Grassle, Hagadorn, Hamner, Hamner, Herdman, Hermes Mianzan, Jackson, Jennifer E. Purcell, Kelly L. Robinson, Kelly R. Sutherland, Kogovšek, Kott, Kylie A. Pitt, Laurence P. Madin, Lavaniegos, Lotan, Lynam, Lynam, Macgillivray, Madin, Martin, Martin, Mary Beth Decker, Mayer, Michael N Dawson, Mills, Mills, Mills, Mills, Nel, Parsons, Pauly, Pauly, Pauly, Pickerill, Purcell, Péron, Quoy, Richardson, Rigby, Robert H. Condon, Russell, Russell, Sheard, Shin-ichi Uye, Stasinska, Stefan Gelcich, Steven H.D. Haddock, Strathmann, Sutherland, Uye, Uye, Vinogradov, William M. Graham   +81 more
core   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

False Vacuum Chaotic Inflation: The New Paradigm? [PDF]

, 1994
Recent work is reported on inflation model building in the context of supergravity and superstrings, with special emphasis on False Vacuum (`Hybrid') Chaotic Inflation.
A. D. Linde, A. D. Linde, A. D. Linde, A. Linde, A. R. Liddle, A. S. Goncharov, E. Copeland, F. C. Adams, K. Freese, K. Olive   +9 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spatio-temporal analysis of air pollution dynamics over Bangalore city during second wave of COVID-19

Natural Hazards Research
The country wide lockdown implemented during 27th April to 14th June 2021 in order to prevent the spread of COVID-19 during the second wave in India. Effect of the restricted lockdown resulted in improved air quality.
Iranna Gogeri, K.C. Gouda, S.T. Aruna
doaj   +1 more source

From normative towards positive epistemology: Problem of scientific fact [PDF]

Sociološki Pregled, 2009
In this article author provides a sketch of a twist from normative towards descriptive epistemology as a result of transformation of contemporary philosophy during the main occurrence known as Linguistic Turn.
Brdar Milan
doaj   +1 more source