Results 51 to 60 of about 1,356,440 (380)

Proteomic analysis of RCL2 paraffin‐embedded tissues [PDF]

Journal of Cellular and Molecular Medicine, 2008
AbstractHistopathological diagnosis in most of the world's hospitals is based upon formalin‐fixed and paraffin‐embedded (FFPE) tissues. Although this standard fixation and embedding procedure keeps the tissue in excellent form for morphological and immunohistological analysis, FFPE is inappropriate for nucleic acids and protein studies. We investigated
Bellet, V., Boissière, F., Bibeau, F., Desmetz, C., Berthe, M.-L., Rochaix, P., Maudelonde, T., Mangé, Alain, Solassol, J.   +8 more
openaire   +4 more sources

A novel tissue microarray instrumentation:The HT-1 tissue microarrayer

Indian Journal of Pathology and Microbiology, 2012
Background: Tissue microarray (TMA) is a novel and useful tool to efficiently analyze gene expression in histological tissues. Aim: Cost-efficient and easy to use automated tissue arrayers will provide a better instrumentation to generate TMAs.
Jun Yang, Mingjuan Zhang, Baoshan Su, XiaoLi Chen, AnJing Kang   +4 more
doaj   +1 more source

Distal Urogenital Anatomy of Male Southern Coal Skinks, Plestiodon anthracinus pluvialis (Reptilia: Scincidae) [PDF]

, 2018
I investigated the morphology and histology of the distal urogenital anatomy of male southern coal skinks (Plestiodon anthracinus pluvialis) from reproductively active individuals collected in Arkansas in order to provide comparative information with ...
Trauth, Stanley E.
core   +3 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

An Optimized Method of Metabolite Extraction from Formalin-Fixed Paraffin-Embedded Tissue for GC/MS Analysis. [PDF]

PLoS ONE, 2015
Formalin-fixed paraffin-embedded (FFPE) tissue specimens constitute a highly valuable source of clinical material for retrospective molecular studies. However, metabolomic assessment of such archival material remains still in its infancy. Hence, there is
Anna Wojakowska, Łukasz Marczak, Karol Jelonek, Krzysztof Polanski, Piotr Widlak, Monika Pietrowska   +5 more
doaj   +1 more source

Degeneration of postovulatory follicles in the Iberian sardine Sardina pilchardus: structural changes and factors affecting resorption [PDF]

, 2007
Inaccuracy in the aging of postovulatory follicles (POFs) and in estimating the effect of temperature on the resorption rate of POFs may introduce bias in the determination of the daily spawning age classes with the daily egg production method (DEPM). To
Ganias , Konstantinas, Nunes, Cristina, Stratoudakis, Yorgos   +2 more
core  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Comparison of Varying Tissue Freezing Methods on Murine Colonic Tissue [PDF]

, 2018
Histology often requires a tissue specimen to be embedded so that it may be sectioned, stained, and mounted on a microscope slide for viewing. One common method of tissue embedding for rapid histology is freezing, since freezing allows tissue to be ...
Hughes, James
core   +2 more sources

Morphometric study of myocardial changes during doxorubicin-induced cardiomyopathy in mice [PDF]

, 1988
Doxorubicin (DOX) is one of the most effective anti-cancer drugs in oncology, but may cause a cumulative dose-dependent cardiomyopathy in a number of cancer patients. The effect of DOX on the heart was studied in mice treated with i.v. injections of 2 mg/
Feijen, Jan, Mross, Klaus, Pinedo, Herbert M., Poort, Jos S.E. van der, Schlüper, Henny M.M., Velzen, Dick van, Vijgh, Wim J.F. van der   +6 more
core   +3 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source