Results 21 to 30 of about 736 (155)

Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator [PDF]

Magnetic Resonance, 2021
The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (
F. Ellermann, A. Pravdivtsev, J.-B. Hövener   +2 more
doaj   +1 more source

Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI. [PDF]

J Magn Reson Imaging
ABSTRACT Conventional Magnetic Resonance Imaging (MRI) offers limited sensitivity for direct metabolic and molecular imaging using non‐proton nuclei due to low thermal nuclear spin polarization. Hyperpolarization (HP) technologies increase nuclear spin polarization by several orders of magnitude, overcoming this limitation to enable in vivo studies of ...
Khan AS, Laustsen C.
europepmc   +2 more sources

Understanding Parahydrogen Hyperpolarized Urine Spectra: The Case of Adenosine Derivatives

Molecules, 2022
Parahydrogen hyperpolarization has emerged as a promising tool for sensitivity-enhanced NMR metabolomics. It allows resolution and quantification of NMR signals of certain classes of low-abundance metabolites that would otherwise be undetectable ...
Kerti Ausmees, Nele Reimets, Indrek Reile   +2 more
doaj   +1 more source

Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

Advanced Science, 2023
Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment
Luca Nagel, Martin Gierse, Wolfgang Gottwald, Zumrud Ahmadova, Martin Grashei, Pascal Wolff, Felix Josten, Senay Karaali, Christoph A. Müller, Sebastian Lucas, Jochen Scheuer, Christoph Müller, John Blanchard, Geoffrey J. Topping, Andre Wendlinger, Nadine Setzer, Sandra Sühnel, Jonas Handwerker, Christophoros Vassiliou, Frits H.A. vanHeijster, Stephan Knecht, Michael Keim, Franz Schilling, Ilai Schwartz   +23 more
doaj   +1 more source

Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques [PDF]

Analytical Chemistry, 2022
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen, parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a century. pH2 was used as a model system in the early days of quantum mechanics (1) and is used for fueling rockets as well as combustion-free cars today.
Schmidt, Andreas B., Bowers, C. Russell, Buckenmaier, Kai, Chekmenev, Eduard Y., de Maissin, Henri, Eills, James, Ellermann, Frowin, Glöggler, Stefan, Gordon, Jeremy W., Knecht, Stephan, Koptyug, Igor V., Kuhn, Jule, Pravdivtsev, Andrey N., Reineri, Francesca, Theis, Thomas, Them, Kolja, Hövener, Jan-Bernd   +16 more
openaire   +4 more sources

Parahydrogen‐Induced Hyperpolarization of Gases

Angewandte Chemie International Edition, 2020
AbstractImaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization.
Kirill V. Kovtunov, Igor V. Koptyug, Marianna Fekete, Simon B. Duckett, Thomas Theis, Baptiste Joalland, Eduard Y. Chekmenev   +6 more
openaire   +3 more sources

Parahydrogen-Induced Polarization Relayed via Proton Exchange [PDF]

Journal of the American Chemical Society, 2021
The sensitivity of NMR and MRI can be boosted via hyperpolarization of nuclear spins. However, current methods are costly, polarization is relatively low, or applicability is limited. Here, we report a new hyperpolarization method combining the low-cost, high polarization of hydrogenative parahydrogen-induced polarization (PHIP) with the flexibility of
Kolja Them, Frowin Ellermann, Andrey N. Pravdivtsev, Oleg G. Salnikov, Ivan V. Skovpin, Igor V. Koptyug, Rainer Herges, Jan-Bernd Hövener   +7 more
openaire   +3 more sources

1, 3-Butadienen Hydrogenation on Supported Pd-Sn Bimetallic Catalysts Investigated by Parahydrogen-induced Polarization

Chinese Journal of Magnetic Resonance, 2022
The selective hydrogenation of 1, 3-butadiene over Pd-Sn/Al2O3 bimetallic catalysts was investigated by heterogeneous parahydrogen-induced polarization (PHIP). A series of Pd1-Snx/Al2O3 bimetallic catalysts with different Pd/Sn ratios were synthesized by
Han HU, Wei-yu WANG, Jun XU, Feng DENG
doaj   +1 more source

Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange

Molecules, 2020
Signal Amplification by Reversible Exchange (SABRE), a hyperpolarization technique, has been harnessed as a powerful tool to achieve useful hyperpolarized materials by polarization transfer from parahydrogen.
Sarah Kim, Sein Min, Heelim Chae, Hye Jin Jeong, Sung Keon Namgoong, Sangwon Oh, Keunhong Jeong   +6 more
doaj   +1 more source

Parahydrogen-induced polarization enables the single-scan NMR detection of a 236 kDa biopolymer at nanomolar concentrations

Scientific Reports, 2023
Nuclear magnetic resonance (NMR) experiments utilizing parahydrogen-induced polarization (PHIP) were performed to elucidate the PHIP activity of the synthetic 236 kDa biopolymer poly-γ-(4-propargyloxy)-benzyl-L-glutamate) (PPOBLG).
Franziska Theiss, Laura Wienands, Jonas Lins, Marcel Alcaraz-Janßen, Christina M. Thiele, Gerd Buntkowsky   +5 more
doaj   +1 more source