Results 61 to 70 of about 736 (155)

13C MRI of hyperpolarized pyruvate at 120 µT

Scientific Reports
Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging.
Nicolas Kempf, Rainer Körber, Markus Plaumann, Andrey N. Pravdivtsev, Jörn Engelmann, Johannes Boldt, Klaus Scheffler, Thomas Theis, Kai Buckenmaier   +8 more
doaj   +1 more source

Continuous‐Wave (CW) Photo‐CIDNP NMR Spectroscopy: A Tutorial

Magnetic Resonance in Chemistry, Volume 63, Issue 12, Page 1020-1034, December 2025.
ABSTRACT Photo‐chemically induced dynamic nuclear polarisation (photo‐CIDNP) is a nuclear spin‐selective magnetic resonance phenomenon that has traditionally been used to mechanistically study chemical reactions involving the (transient) formation of radical molecular species, extract EPR observables of short‐lived radicals, probe biomolecular ...
Lars T. Kuhn, Míriam Pérez‐Trujillo
wiley   +1 more source

Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields

Magnetochemistry
Hyperpolarization (HP) techniques, such as Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and dissolution Dynamic Nuclear Polarization (d-DNP), significantly enhance the sensitivity of nuclear magnetic ...
Garrett L. Wibbels, Clementinah Oladun, Tanner Y. O’Hara, Isaiah Adelabu, Joshua E. Robinson, Firoz Ahmed, Zachary T. Bender, Anna Samoilenko, Joseph Gyesi, Larisa M. Kovtunova, Oleg G. Salnikov, Igor V. Koptyug, Boyd M. Goodson, W. Michael Snow, Eduard Y. Chekmenev, Roman V. Shchepin   +15 more
doaj   +1 more source

Reversible Parahydrogen Induced Hyperpolarization of 15N in Unmodified Amino Acids Unraveled at High Magnetic Field

Advanced Science, 2023
Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism and cell regulation in both plants and humans. NMR provides interesting opportunities to investigate these metabolic pathways, yet lacks sensitivity, especially in case
Ewoud Vaneeckhaute, Jean‐Max Tyburn, James G. Kempf, Johan A. Martens, Eric Breynaert   +4 more
doaj   +1 more source

Optimal Variable Flip Angle Schemes for Hyperpolarized MR Kinetic Modeling Robust to RF Field Variations

NMR in Biomedicine, Volume 38, Issue 11, November 2025.
Optimization of variable flip angle schemes that minimize the variances of conversion rate estimates derived from hyperpolarized magnetic resonance experiments. Simulations based on in vitro experiments validated the improved parameter estimation and robustness of the optimized variable flip angle schemes.
Marie Frederikke Garnæs, Rie Beck Olin, Pernille R. Jensen, Jan Henrik Ardenkjaer‐Larsen, Kristoffer Hougaard Madsen, Lars G. Hanson   +5 more
wiley   +1 more source

PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI

Scientific Reports, 2021
Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is ...
Alexandra Svyatova, Vitaly P. Kozinenko, Nikita V. Chukanov, Dudari B. Burueva, Eduard Y. Chekmenev, Yu-Wen Chen, Dennis W. Hwang, Kirill V. Kovtunov, Igor V. Koptyug   +8 more
doaj   +1 more source

Deep Learning for Hyperpolarized NMR of Intrinsically Disordered Proteins without Resolution Loss: Access to Short‐Lived Intermediates

Chemistry – A European Journal, Volume 31, Issue 59, October 22, 2025.
Abstract The inherently low sensitivity of solution‐state Nuclear Magnetic Resonance (NMR) has long limited its ability to characterize transient biomolecular states at atomic resolution. While dissolution dynamic nuclear polarization (dDNP) offers a compensating signal enhancement, its broader use has been hindered by rapid polarization decay, causing
Ertan Turhan, Christopher Pötzl, Dörte Brandis, Federico Faglia, Milan Zachrdla, Dennis Kurzbach   +5 more
wiley   +1 more source

Hyperpolarization of [13C]formate using parahydrogen

Journal of Magnetic Resonance Open
Sodium [13C]formate was successfully hyperpolarized using parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [13C]formate was hyperpolarized using homogeneous hydrogenation of the corresponding unsaturated precursor ...
Dudari B. Burueva, Sergey V. Sviyazov, Nikita V. Chukanov, Nazim R. Mustafin, Oleg G. Salnikov, Eduard Y. Chekmenev, Kirill V. Kovtunov, Igor V. Koptyug   +7 more
doaj   +1 more source

Density Functional Theory–Spectroscopy Integrated Identification Method Encompassing Experimental and Theoretical Analyses for Designer Drug Stimulants

Advanced Intelligent Systems, Volume 7, Issue 10, October 2025.
A novel approach integrates gas chromatography‐mass spectrometry with infrared, Raman, and nuclear magnetic resonance spectroscopy plus density functional theory to detect synthetic drugs. Quantum hyperpolarization further boosts NMR sensitivity for low‐concentration samples, improving detection accuracy in complex mixtures and offering promising ...
Keunhong Jeong, Youngjoon Jeon, Sein Min, Tae In Ryu, Young Wook Yoon, Yoonjae Cho, Seung‐Ryul Hwang, Hye Jin Jeong, Sung Soo Kim   +8 more
wiley   +1 more source

Parahydrogen-induced polarization of 14N nuclei

Angewandte Chemie International Edition
Hyperpolarization techniques provide a dramatic increase in sensitivity of nuclear magnetic resonance spectroscopy and imaging. In spite of the outstanding progress in solution-state hyperpolarization of spin-1/2 nuclei, hyperpolarization of quadrupolar nuclei remains challenging.
Salnikov, Oleg G., Trofimov, Ivan A., Bender, Zachary T., Trepakova, Alexandra I., Xu, Jingyan, Wibbels, Garrett L., Shchepin, Roman V., Koptyug, Igor V., Barskiy, Danila A.   +8 more
openaire   +4 more sources