Results 71 to 80 of about 33,423 (302)

Parallel Manipulators with Lower Mobility [PDF]

open access: yes, 2006
Parallel manipulators with lower mobility (LM-PMs) are multi-loop mechanisms with less than six degrees of freedom (dofs). This type of manipulators has attracted the attention both of academic researchers and of industries since the early appearance of the DELTA robot (Clavel 1988). The DELTA robot showed that, when the manipulation task requires less
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Dynamic Modeling and Response Analysis of an Optical Machining Robot with Prismatic Joint Clearance

open access: yesApplied Sciences
The accuracy and stability of robotic systems are significantly influenced by joint clearances, especially in precision applications like optical mirror polishing.
Shuaishuai Zhu   +3 more
doaj   +1 more source

A Comparison Study on Motion/Force Transmissibility of Two Typical 3-DOF Parallel Manipulators: The Sprint Z3 and A3 Tool Heads

open access: yesInternational Journal of Advanced Robotic Systems, 2014
This paper presents a comparison study of two important three-degree-of-freedom (DOF) parallel manipulators, the Sprint Z3 head and the A3 head, both commonly used in industry. As an initial step, the inverse kinematics are derived and an analysis of two
Xiang Chen   +3 more
doaj   +1 more source

Singularity Conditions of 3T1R Parallel Manipulators with Identical Limb Structures [PDF]

open access: yes, 2012
International audienceThis paper deals with the singularity analysis of parallel manipulators with identical limb structures performing Schönflies motions, namely, three independent translations and one rotation about an axis of fixed direction (3T1R ...
Amine, Semaan   +4 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

柔性并联机器人的动力规划

open access: yesJixie chuandong, 2013
The dynamic planning of the flexible parallel manipulators is discussed.Firstly the kinematics of the flexible parallel manipulator is analyzed.Secondly,the mathematical model of driving torque minimum was development.Finally,the dynamic planning of ...
丁明, 刘善增
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Simulation of the Lumbar Spine as a Multi-Module Paralel Manipulator

open access: yesApplied Bionics and Biomechanics, 2011
In this paper a simulation of movements of lumbar spine is proposed by using a model with serially connected parallel manipulators. An analysis has been computed for the human spine structure and its movements, in order to simulate the motions and forces
M. Ceccarelli   +3 more
doaj   +1 more source

Space spider crane [PDF]

open access: yes, 1988
A space spider crane for the movement, placement, and or assembly of various components on or in the vicinity of a space structure is described. As permanent space structures are utilized by the space program, a means will be required to transport cargo ...
Bryan, Charles F., Jr.   +4 more
core   +1 more source

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