Results 81 to 90 of about 33,400 (300)

Kinematics, workspace and singularity analysis of a multi-mode parallel robot

open access: yes, 2017
A family of reconfigurable parallel robots can change motion modes by passing through constraint singularities by locking and releasing some passive joints of the robot.
Chablat, Damien   +2 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Kinematic Characteristics of 3-UPU Parallel Manipulator in Singularity and Its Application

open access: yesInternational Journal of Advanced Robotic Systems, 2011
This paper focuses on the kinematic characteristics of the 3‐UPU (universal‐prismatic‐ universal) parallel manipulator in one of singular configurations.
Peng Binbin, Li Zengming, Wu Kai, Sun Yu
doaj   +2 more sources

Changing Assembly Modes without Passing Parallel Singularities in Non-Cuspidal 3-R\underline{P}R Planar Parallel Robots

open access: yes, 2008
This paper demonstrates that any general 3-DOF three-legged planar parallel robot with extensible legs can change assembly modes without passing through parallel singularities (configurations where the mobile platform loses its stiffness).
Bonev, Ilian   +3 more
core  

Positioning Control of Pneumatic Parallel Manipulator.

open access: yesJournal of the Robotics Society of Japan, 1997
This paper describes one of the control methods which attain robust motion control performances of parallel manipulator. We used pneumatic cylinders as a driving actuator, focusing on air compressibility valid for the minute force control and impact absorption in environmental contact.
Masahiro Takaiwa, Toshiro Noritsugu
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

并联机构运动分岔与稳定性分析

open access: yesJixie chuandong, 2008
At singularities, the parallel manipulator will have more than one the motion trends. So the parallel manipulator will lose control. Based on the bifurcation characteristics of a parallel manipulator at singularities, a new method to estimate the losing ...
郭瑞琴
doaj  

Extra modes of operation and self motions in manipulators designed for Schoenflies motion

open access: yes, 2015
We study 4-UPU parallel manipulators performing Schoenflies motion and show that they can have extra modes of operation with 3 degrees of freedom, depending on the geometric parameters of the manipulators.
Coste, Michel, Demdah, Kartoue Mady
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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