Results 61 to 70 of about 1,680,393 (297)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Master assisted cooperative control of human and robot [PDF]
, 1996 A cooperative control approach between human and robot takes an important role to carry out various tasks in hazardous environments or space. In this case, a robot is operated based on the cooperation between direct human control and autonomous robot ...
Inoue, Hiroyuki +3 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Robot Navigation in Dense Crowds: Statistical Models and Experimental Studies of Human Robot Cooperation [PDF]
, 2013 This thesis explores the problem of mobile robot navigation in dense human crowds. We begin by considering a fundamental impediment to classical motion planning algorithms called the freezing robot problem: once the environment surpasses a certain level
Trautman, Peter
core +1 more source
Kinematic Analysis and Calibration Experiment of a 2UPU-SP+RR Hybrid Robot
IEEE AccessHybrid robots integrate the advantages of both serial and parallel mechanism, demonstrating significant potential for complex surface machining of aluminum alloys.
Xiaoyu He +3 more
doaj +1 more source
Design and Isokinetic Training Control Method of Leg Press Training Device
Applied Sciences, 2019 Lower-limb function in elderly people gradually degenerates with age, and poor rehabilitation conditions preventing the elderly from receiving scientific rehabilitation training result in the decline of social labor force and the increased economic ...
Hongfei Yu +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
An Active helideck testbed for floating structures based on a Stewart-Gough platform [PDF]
, 2008 A parallel robot testbed based on Stewart-Gough platform called Active-helideck is designed, developed and tested as a helicopter floating helideck. The objective of this testbed is to show the advantages of helicopters that use an active helideck upon ...
Ferre Pérez, Manuel +4 more
core
Design and Analysis of a Lower Limb Rehabilitation Training Component for Bedridden Stroke Patients
Machines, 2021 Carrying out the immediate rehabilitation interventional therapy will better improve the curative effect of rehabilitation therapy, after the condition of bedridden stroke patients becomes stable.
Xusheng Wang +6 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source