Results 41 to 50 of about 26,290 (267)

Configuration Design and Size Optimization of a High-Precision Novel Parallel Pointing Mechanism Based on Interference Separation

Chinese Journal of Mechanical Engineering
Pointing mechanism is widely used in aerospace field, and its pointing accuracy and stability have high requirements. The pointing mechanism will be affected by external interference when it works.
Sen Wang, Shihua Li, Xueyan Han, Jiahao Wei, Xueyuan Gao, Hongyu Xu   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Theoretical Analysis and Experiment of the Five DOF Hybrid Robot P(RPR/RP)RR

IEEE Access
To meet the demands of machining new energy vehicles aluminum alloy structures, this paper introduced a five degree-of-freedom (DOF) hybrid robot, P(RPR/RP)RR, and conducted a systematic investigation into its kinematics, stiffness, and preliminary ...
Xuejian Ma, Xiaoyu He, Yundou Xu, Jiantao Yao, Yongsheng Zhao   +4 more
doaj   +1 more source

Actuation Spaces Synthesis of Lower-Mobility Parallel Mechanisms Based on Screw Theory

Chinese Journal of Mechanical Engineering, 2021
The lower-mobility parallel mechanism has been widely used in the engineering field due to its numerous excellent characteristics. However, little work has been devoted to the actuator selection and placement that best satisfy the system’s functional ...
Shihua Li, Yanxia Shan, Jingjun Yu, Yaxiong Ke   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Parallel Robots in Construction [PDF]

Proceedings of the International Symposium on Automation and Robotics in Construction (IAARC), 2005
Parallel robots have been in existence since the first half of the 20 century. Applications of parallel robots have ranged from tire testing machines to robots for performing surgery. The high load-to-weight ratio and high stiffness of parallel mechanisms sets them apart from more common serial robots.
Kamel S. Saidi, Alan M. Lytle
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Kinematic Analysis and Calibration Experiment of a 2UPU-SP+RR Hybrid Robot

IEEE Access
Hybrid robots integrate the advantages of both serial and parallel mechanism, demonstrating significant potential for complex surface machining of aluminum alloys.
Xiaoyu He, Xuejian Ma, Yu Wang, Yundou Xu   +3 more
doaj   +1 more source

Design and Isokinetic Training Control Method of Leg Press Training Device

Applied Sciences, 2019
Lower-limb function in elderly people gradually degenerates with age, and poor rehabilitation conditions preventing the elderly from receiving scientific rehabilitation training result in the decline of social labor force and the increased economic ...
Hongfei Yu, Hongbo Wang, Yaxin Du, Xinyu Hu, Ziyu Liao   +4 more
doaj   +1 more source