Results 81 to 90 of about 18,630 (214)

Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections

Viruses, 2013
Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract.
Antonieta Guerrero-Plata
doaj   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Complete Genome Sequence of the Avian Paramyxovirus Serotype 5 Strain APMV-5/budgerigar/Japan/TI/75

, 2016
Here, we report the complete genome sequence of the avian paramyxovirus serotype 5 strain APMV-5/budgerigar/Japan/TI/75, which was determined using the Illumina MiSeq platform. The determined sequence shares 97% homology and similar genetic features with
Tuchiya, Kotaro, Hiono, Takahiro, Sakoda, Yoshihiro, Okamatsu, Masatoshi, Matsuno, Keita, Lin, Zhifeng   +5 more
core   +1 more source

Phylogenetic analysis of the promoter element 2 of paramyxo- and filoviruses

Microbiology Spectrum
Paramyxo- and filovirus genomes are equipped with bipartite promoters at their 3' ends to initiate RNA synthesis. The two elements, the primary promoter element 1 (PE1) and the secondary promoter element 2 (PE2), are separated by a spacer region that ...
Shoichi Ashida, Shohei Kojima, Takashi Okura, Fumihiro Kato, Wakako Furuyama, Shuzo Urata, Yusuke Matsumoto   +6 more
doaj   +1 more source

Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits

Viruses, 2019
The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited.
Theocharis Tsoleridis, Joseph G. Chappell, Elodie Monchatre-Leroy, Gérald Umhang, Mang Shi, Malcolm Bennett, Rachael E. Tarlinton, C. Patrick McClure, Edward C. Holmes, Jonathan K. Ball   +9 more
doaj   +1 more source

Cooperative Neuraminidase Activity in a Paramyxovirus

Virology, 1995
Paramyxoviruses possess neuraminidase (NA) activity, i.e., the ability to cleave sialic acid from membrane-bound and soluble glycoconjugates. The activity is associated with a homotetrameric, surface glycoprotein spike, called the hemagglutinin-neuraminidase.
Mahon, Paul J., Deng, Ruitang, Mirza, Anne M., Iorio, Ronald M.   +3 more
openaire   +2 more sources

PS2-63 A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2

, 2009
Diverse members of the Paramyxovirus family of negative-strand RNA viruses effectively suppress host innate immune responses through the actions of their V proteins.
Jean-Patrick Parisien, Barber, Glen, Akihiko Komuro, Ramachandran, Aparna, Robert D. Wojahn, Aparna Ramachandran, Darja Bamming, Bamming, Darja, Parisien, Jean-Patrick, Glen Barber, Horvath, Curt M, Rodriguez, Jason J, Wojahn, Robert D, Jason J. Rodriguez, Komuro, Akihiko, Curt M. Horvath   +15 more
core   +1 more source

Genotype I Newcastle Disease Virus, Isolated from Wild Duck, Can Protect Chickens Against Newcastle Disease Caused by Genotype VII

Pathogens
Newcastle disease viruses (NDVs) circulating among wild birds and poultry may differ in virulence. Some NDVs cause devastating outbreaks in chickens. The NDV/duck/Moscow/3639/2008 (d3639) strain was isolated from a wild duck.
Elizaveta Boravleva, Anastasia Treshchalina, Daria Gordeeva, Alexandra Gambaryan, Alla Belyakova, Irina Gafarova, Alexey Prilipov, Galina Sadykova, Simone Adams, Tatiana Timofeeva, Natalia Lomakina   +10 more
doaj   +1 more source

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling

, 2018
Paramyxovirus V proteins are known antagonists of the RIG-I-like receptor (RLR)-mediated interferon induction pathway, interacting with and inhibiting the RLR MDA5.
Megan L. Shaw, Leighland J. Feinman, Maria T. Sánchez-Aparicio, Adolfo García-Sastre   +3 more
core   +1 more source

A paramyxovirus-like model for Ebola virus bipartite promoters

, 2020
International audienceParamyxo- and filovirus nucleocapsids (NCs) have bipartite promoters at their 3′ ends to initiate RNA synthesis. The 2 elements, promoter element 1 (PE1) and promoter element 2 (PE2), are separated by a spacer region that must be ...
Philippe le Mercier, Daniel Kolakofsky, Irina Gutsche, Kolakofsky, Daniel, Gutsche, Irina, Le Mercier, Philippe, Gutsche I, le Mercier P, Kolakofsky D   +8 more
core   +1 more source