Results 61 to 70 of about 15,173 (180)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

The Versatility of Paramyxovirus RNA Polymerase Stuttering [PDF]

Journal of Virology, 1999
ABSTRACT Paramyxoviruses cotranscriptionally edit their P gene mRNAs by expanding the number of Gs of a conserved A n G n run. Different viruses insert different distributions of guanylates, e.g., Sendai virus inserts a single G, whereas parainfluenza virus type 3 inserts one to six
Hausmann, Stéphane, Garcin, Dominique, Delenda, Christophe, Kolakofsky, Daniel   +3 more
openaire   +3 more sources

The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms

eLife
Paramyxovirus membrane fusion requires an attachment protein for receptor binding and a fusion protein for membrane fusion triggering. Nipah virus (NiV) attachment protein (G) binds to ephrinB2 or -B3 receptors, and fusion protein (F) mediates membrane ...
Qian Wang, Jinxin Liu, Yuhang Luo, Vicky Kliemke, Giuliana Leonarda Matta, Jingjing Wang, Qian Liu   +6 more
doaj   +1 more source

Kinetic Dependence of Paramyxovirus Entry Inhibition [PDF]

Journal of Virology, 2009
ABSTRACT Peptides derived from conserved heptad repeat (HR) regions of paramyxovirus fusion (F) proteins inhibit viral fusion by interfering with the formation of the fusogenic six-helix bundle structure. Peptide efficacy is affected by the strength of the peptide association with the target virus's complementary HR region. Here, we show that
Porotto, Matteo, Yokoyama, Christine C., Orefice, Gianmarco, Kim, Han-Sung, Aljofan, Mohamed, Mungall, Bruce A., Moscona, Anne   +6 more
openaire   +3 more sources

Cohorts of immature Pteropus bats show interannual variation in Hendra virus serology

Journal of Animal Ecology, Volume 95, Issue 3, Page 521-537, March 2026.
Pteropus bat with offspring, photo taken by Manuel Ruiz‐Aravena. Abstract Understanding the drivers of seasonal disease outbreaks remains a fundamental challenge in disease ecology. Periodic outbreaks can be driven by several seasonally varying factors, including pulses of susceptible individuals through births, changes in host behaviour and social ...
Daniel E. Crowley, Caylee A. Falvo, Chris K. Grant, Benny Borremans, Tamika J. Lunn, Manuel Ruiz‐Aravena, Evelyn Benson, Clifton D. McKee, Daniel J. Becker, Devin N. Jones, Trenton Bushmaker, Y. Tina Yu, Michelle Michie, Adrienne S. Dale, Lianying Yan, Spencer L. Sterling, Christopher C. Broder, Laura B. Goodman, Rasa Petraityte‐Burneikiene, Eric D. Laing, Ina L. Smith, Vincent J. Munster, Agnieszka Rynda‐Apple, Alison J. Peel, Raina Plowright   +24 more
wiley   +1 more source

Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production

mBio, 2020
Human respiratory syncytial virus (HRSV) envelope glycoproteins traffic to assembly sites through the secretory pathway, while nonglycosylated proteins M and N are present in HRSV inclusion bodies but must reach the plasma membrane, where HRSV assembly ...
Ricardo S. Cardoso, Lucas Alves Tavares, Bruna Lais S. Jesus, Miria F. Criado, Andreia Nogueira de Carvalho, Juliano de Paula Souza, Sukhmani Bedi, Marcos Michel de Souza, Maria Lucia Silva, Guilherme Pauperio Lanfredi, Brenda Cristina Vitti, Orlando Bonito Scudero, Vitor Marcel Faça, Akira Ono, Armando M. Ventura, Luis Lamberti P. daSilva, Eurico Arruda   +16 more
doaj   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation

Viruses, 2019
Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the Paramyxovirus family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein.
Tahir Malik, Laurie Ngo, Trent Bosma, Steven Rubin   +3 more
doaj   +1 more source

Global Epidemiology and Disease Burden of Human Parainfluenza Virus in Adults: A Systematic Review

Reviews in Medical Virology, Volume 36, Issue 1, January 2026.
ABSTRACT Parainfluenza virus (PIV) is a common cause of respiratory illness in children and immunocompromised adults, but little is known about its epidemiology or disease burden in the general adult population. This review evaluates published global epidemiological and disease burden for PIV in adults, including high‐risk patients (immunocompromised ...
Oliver Martyn, Clemens Vlasich, Veronika Khariv, Lauren C. Boudewyn, Peter J. M. Openshaw, Rolf Kramer   +5 more
wiley   +1 more source