Results 61 to 70 of about 5,226 (177)

QM/MM Description of Newly Selected Catalytic Bioscavengers Against Organophosphorus Compounds Revealed Reactivation Stimulus Mediated by Histidine Residue in the Acyl-Binding Loop

Frontiers in Pharmacology, 2018
Butyrylcholinesterase (BChE) is considered as an efficient stoichiometric antidote against organophosphorus (OP) poisons. Recently we utilized combination of calculations and ultrahigh-throughput screening (uHTS) to select BChE variants capable of ...
Alexander Zlobin, Yuliana Mokrushina, Stanislav Terekhov, Arthur Zalevsky, Arthur Zalevsky, Tatiana Bobik, Anastasiya Stepanova, Maria Aliseychik, Olga Kartseva, Sergey Panteleev, Andrey Golovin, Andrey Golovin, Alexey Belogurov, Alexey Belogurov, Alexey Belogurov, Alexander Gabibov, Alexander Gabibov, Ivan Smirnov   +17 more
doaj   +1 more source

Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms. [PDF]

PLoS ONE, 2010
Epidemiological studies link organophosphorus pesticide (OP) exposures to asthma, and we have shown that the OPs chlorpyrifos, diazinon and parathion cause airway hyperreactivity in guinea pigs 24 hr after a single subcutaneous injection.
Becky J Proskocil, Donald A Bruun, Charles M Thompson, Allison D Fryer, Pamela J Lein   +4 more
doaj   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Fototermičke bioanalitičke metode za testiranje toksičnosti pesticida [PDF]

, 2003
This paper describes bioanalytical methods and biosensors which rely on cholinesterase (ChE) inhibition and can be used to detect and test the toxicity of organophosphate (OP) and carbamate pesticides. Particular attention is given to the combined use of
Lea Pogačnik, Mladen Franko
core   +1 more source

Durable Physically Mixed Microporous and Mesoporous MOFs/Nanofiber Aerogel 3D Composites for Effective Toxic Gas Capture and Organophosphonate Detoxification

Advanced Functional Materials, Volume 36, Issue 13, 12 February 2026.
Ultralight 3D nanofibrous aerogels embedded with metal‐organic frameworks effectively capture and neutralize toxic gases and organophosphonates. Incorporating mesoporous UiO‐66‐NH2 and HKUST‐1 into PAN/PVP fibers enables high MOF loading while maintaining mechanical strength and structural stability.
Mai O. Abdelmigeed, Muhammed Ziauddin Ahmad Ebrahim, John J. Mahle, Brandon B. Blount, Gregory W. Peterson, Saad A. Khan, Gregory N. Parsons   +6 more
wiley   +1 more source

Effect of Paraoxon on the Oxidative Stress Indices and Lactate Dehydrogenase Activity in Rat Liver

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Paraoxon (active metabolite of parathion) is one of the most toxic organophosphate (OP) compounds. Acetyl cholinesterase inhibition is the main acute toxic mechanisms of OPs.
E Ghani, M Mohammadi, M Jafari, A Khoshbaten, AR Asgari   +4 more
doaj  

Development of new analytical tools for monitoring of cardiovascular disease markers – towards the detection of homocysteine-thiolactone [PDF]

, 2015
Poster presented at the 4th International Conference on Bio-Sensing Technology, 10-13 May 2015, Lisbon ...
Almeida, M. Gabriela, Monteiro, Tiago, Oliveira, Francisco, Pereira, Sofia A., Silveira, Célia M.   +4 more
core  

An acetylcholinesterase biosensor for determination of low concentrations of Paraoxon and Dichlorvos [PDF]

, 2011
The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed.
Arduini, F, Bencivenga, U, Di Tuoro, D, Lepore, M, Mita, D G, Moscone, D, Portaccio, M, Vitiello, A   +7 more
core   +1 more source

Enhanced Recognition via Defect Engineered Amorphous Metal–Organic Framework for Sensitive and Stable Pesticide Biosensor

Advanced Science, Volume 13, Issue 7, 3 February 2026.
A defect‐engineered assembly strategy is reported for the in situ encapsulation of acetylcholinesterase (AChE) into amorphous MOF‐74, endowing the composite with superior catalytic activity and target recognition capability. Leveraging these structural advantages, a sensitive and stable biosensor is constructed for the detection of paraoxon pesticide ...
Changshun Su, Xiangyu Zhai, Meng Zhang, Mengxue Li, Xinru Zhang, Chunyan Sun, Xu Yan, Hongxia Li   +7 more
wiley   +1 more source

Organophosphorous Pesticide Detection in Olive Oil by Using a Miniaturized, Easy-to-Use, and Cost-Effective Biosensor Combined with QuEChERS for Sample Clean-Up

Sensors, 2016
Herein, we report a portable electrochemical biosensor based on butyrylcholinesterase (BChE) immobilized on carbon black (CB)-modified screen-printed electrodes (SPEs) for the detection of organophosphorous pesticides in olive oil.
Fabiana Arduini, Matteo Forchielli, Viviana Scognamiglio, Kozitsina Alisa Nikolaevna, Danila Moscone   +4 more
doaj   +1 more source