Results 181 to 190 of about 16,430 (217)

Paraoxonase 1 and atherosclerosis‐related diseases

BioFactors, 2019
AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles.
Jelena Kotur‐Stevuljević, Jelena Vekić, Aleksandra Stefanović, Aleksandra Zeljković, Ana Ninić, Jasmina Ivanišević, Milica Miljković, Miron Sopić, Jelena Munjas, Marija Mihajlović, Slavica Spasić, Zorana Jelić‐Ivanović, Vesna Spasojević‐Kalimanovska   +12 more
openaire   +4 more sources

Macrophage paraoxonase 1 (PON1) binding sites

Biochemical and Biophysical Research Communications, 2008
Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties. PON1 was shown to protect macrophages from oxidative stress, to inhibit macrophage cholesterol biosynthesis, and to stimulate HDL-mediated cholesterol efflux from the cells. The aim of the present study was to characterize macrophage PON1
Michal, Efrat, Michael, Aviram
openaire   +2 more sources

Paraoxonase 1: Genetics and Activities During Aging

Rejuvenation Research, 2008
The increasing longevity of the population, one of the most important issues throughout the planet, is a very complex phenomenon (trait), likely resulting from a variety of environmental determinants interacting with and modulated by genetic mechanisms, mostly devoted to maintenance and repair. In fact, the genes involved in longevity impact upon basic
Marchegiani F., Marra M., Olivieri F., Cardelli M., James R. W., Boemi M., FRANCESCHI, CLAUDIO   +6 more
openaire   +3 more sources

RELATIONSHIP OF ADIPONECTIN TO SERUM PARAOXONASE 1

Atherosclerosis Supplements, 2008
Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups ...
Laszlo, Bajnok, Eva, Csongradi, Ildiko, Seres, Zsuzsa, Varga, Sara, Jeges, Attila, Peti, Zsolt, Karanyi, Attila, Juhasz, Emese, Mezosi, Endre V, Nagy, Gyorgy, Paragh   +10 more
openaire   +2 more sources

Systemic Inflammation, Intestine, and Paraoxonase-1

2014
Serum paraoxonase 1 (PON1) has been shown to act as an important guardian against cellular damage from oxidized lipids in low-density lipoprotein (LDL), plasma membrane, against toxic agents such as pesticide residues including organophosphates and against bacterial endotoxin.
Ladan, Vakili, Kaveh Daniel, Navab, Maryam, Shabihkhani, Nasim, Pourtabatabaei, Samra, Vazirian, Zarina, Barseghian, Seyedehsara, Seyedali, Greg, Hough   +7 more
openaire   +2 more sources

Variation in paraoxonase-1 activity and atherosclerosis

Current Opinion in Lipidology, 2009
Paraoxonase-1 (PON1) is an HDL-associated protein of 354 amino acids with a molecular mass of 43 000 Da. It is synthesized in the liver, and in serum it is almost exclusively associated with HDL. PON1 has been reported to be an important contributor to the antioxidant and anti-inflammatory activities of HDL.
Soran, Handrean, Younis, Nahla N., Charlton-Menys, Valentine, Durrington, Paul   +3 more
openaire   +3 more sources

Paraoxonase 1 (PON1) reduces macrophage inflammatory responses

Atherosclerosis, 2013
Paraoxonase 1 (PON1) was suggested to play an anti-inflammatory role. In the present study we questioned whether PON1 has a direct impact on macrophage inflammatory responses, and the possible functional implications of such effects.Ex-vivo studies were performed with bone marrow-derived macrophages (BMDM) harvested from C57BL/6 and human-PON1 ...
Saar, Aharoni, Michael, Aviram, Bianca, Fuhrman   +2 more
openaire   +2 more sources

Paraoxonase 1 Gene L55M Polymorphism and Paraoxonase 1 Activity in Obstructive Sleep Apnea Patients

2018
The antioxidant enzyme paraoxonase-1 (PON1) may limit oxidative stress in the development of cardiovascular diseases (CVD) and obstructive sleep apnea (OSA). The aim of the study was to determine PON1 gene L55M polymorphism in OSA-positive and OSA-negative subjects, along with paraoxonase activity of the enzyme (PON1-act).
A, Płóciniczak, A, Baszczuk, A, Ludziejewska, H, Winiarska, S, Michalak, G, Kasprzak, D, Formanowicz, S, Cofta, E, Wysocka   +8 more
openaire   +2 more sources

Paraoxonase-1 genetic polymorphisms in organophosphate metabolism

Toxicology, 2019
Organophosphates (OPs) are a class of chemicals commonly used in agriculture as pesticides, that can often lead to severe toxicity in humans. Paraoxonase-1 (PON1) belongs to a family of A-esterases and hydrolyses several OPs while also serving other biological roles.
Efthimios Dardiotis, Athina-Maria Aloizou, Vasileios Siokas, Zisis Tsouris, Dimitrios Rikos, Chrysa Marogianni, Michael Aschner, Leda Kovatsi, Dimitrios P. Bogdanos, Aristidis Tsatsakis   +9 more
openaire   +2 more sources

Paraoxonase 1 and Postprandial Lipemia

2008
Risk factors for coronary heart disease (CHD) include decreased insulin sensitivity and glucose intolerance, hypertension, increased body fat mass, unfavorable body fat distribution, the prothrombotic state and dyslipidemia. A clustering of these metabolic disturbances is also seen in Insulin Resistance and the metabolic syndrome.
A. Alipour, B. Coll, A.P. Rietveld, J. Marsillach, J. Camps, J. Joven, J.W.F. Elte, M. Castro Cabezas   +7 more
openaire   +1 more source