Results 191 to 200 of about 16,430 (217)

Paraoxonase 1 Mutations in a Turkish Population

Toxicology and Applied Pharmacology, 1999
Human serum paraoxonase 1 (PON1) catalyzes the hydrolysis of certain organophosphate pesticides and nerve gases and so may alter significantly an individual's susceptibility to the toxicity of these chemicals. Moreover, PON1 hydrolyzes lipid peroxides complexed to low density lipoproteins (LDL) and therefore it was suggested that PON1 may be one of the
A S, Aynacioglu, I, Cascorbi, P M, Mrozikiewicz, M, Nacak, E E, Tapanyigit, I, Roots   +5 more
openaire   +2 more sources

Antiepileptic drugs: Impacts on human serum paraoxonase‐1

Journal of Biochemical and Molecular Toxicology, 2016
AbstractSerum paraoxonase (PON1) is a key enzyme related to high‐density lipoprotein (HDL)‐cholesterol particle. It can prevent the oxidation of low‐density lipoprotein (LDL) and HDL. The present article focuses on the in vitro inhibition role of some antiepileptic drugs (AEDs) such as valproic acid, gabapentin, primidone, phenytoin, and levetiracetam ...
Demir, Yeliz, BEYDEMİR, ŞÜKRÜ
openaire   +3 more sources

Paraoxonase-1 promoter polymorphism C???107T and serum apolipoprotein AI interact to modulate serum paraoxonase-1 status

Pharmacogenetics and Genomics, 2005
The objective was to examine the hypothesis that modifications to paraoxonase-1 specific activity (SP, activity per unit mass peptide) could contribute to serum paraoxonase-1 status, a determinant of the clinical efficacy of the enzyme.Enzyme activities and concentrations were determined in a large population (n=912) of patients and controls.
Richard W, James, Barbara, Kalix, Silvana, Bioletto, Marie-Claude, Brulhart-Meynet   +3 more
openaire   +2 more sources

Paraoxonase-1 and Cardiovascular Disease

2008
The oxidation of low-density lipoprotein (LDL) in the artery wall is responsible for the initiation and progression of atherosclerosis. High-density lipoprotein (HDL) on the other hand is protective against atherosclerosis development and can attenuate the oxidation of LDL.
B. Mackness, M.I. Mackness
openaire   +1 more source

Oral squamous cell carcinoma and serum paraoxonase 1

The Journal of Laryngology & Otology, 2013
AbstractBackground:Serum paraoxonase 1 is involved in mechanisms that protect cells from oxidative stress damage. This study aimed to investigate the correlation between serum paraoxonase 1 activity and polymorphisms in patients with oral squamous cell carcinoma.Methods and materials:Fifty-seven patients with oral squamous cell carcinoma and 59 matched
Z Boy, Metin, S, Aydin, M, Unur, B, Cakmakoglu, B, Toptas, G, Hafiz, T, İsbir   +6 more
openaire   +2 more sources

Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma

Molecular Biology Reports, 2010
Paraoxonase is an HDL-associated enzyme that plays a preventive role against oxidative stres. Previous studies suggested that involved an amino acid substitution at position 192 gives rise to two alloenzymes with a low activity (Q allele) and a high activity (R allele) towards paraoxon.
Arzu, Ergen, Onder, Kılıcoglu, Harzem, Ozger, Bedia, Agachan, Turgay, Isbir   +4 more
openaire   +2 more sources

Paraoxonase polymorphisms and coronary heart disease

Lancet, The, 2004
John Danesh
exaly   +2 more sources

Four paraoxonase gene polymorphisms in 11 212 cases of coronary heart disease and 12 786 controls: meta-analysis of 43 studies

Lancet, The, 2004
Hugh Christian Watkins, John Danesh
exaly  

Paraoxonase-2 G148 variant in an aboriginal Canadian girl with non-insulin-dependent diabetes

Lancet, The, 1997
Robert A Hegele, Stephen Scherer
exaly  

Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip

Lancet, The, 2002
Andrew Povey
exaly