Results 141 to 150 of about 40,126 (261)

Mitophagy in cisplatin-induced kidney injury: regulatory mechanisms and therapeutic targets. [PDF]

Ann Med
Yuan C, Jiang J, Ji J, Ni L.
europepmc   +1 more source

Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth via STING‐Mediated Type I Interferon Response in iCCA

Cancer Science, EarlyView.
Through bioinformatic analyses, iCCA cell models, and in vivo xenograft experiments, we show that autophagy inhibition sensitizes iCCA to MEK1/2 blockade by enhancing STING‐dependent type I interferon signaling. These findings support combined MEK1/2 and autophagy inhibition as a promising therapeutic strategy for iCCA. ABSTRACT The RAF–MEK–ERK pathway
Chengqiang Sun, Zheng Gao, Enfu Dong, Liangxia Ding, Shanru Feng, Jiafeng Chen, Pascal Kwangwari, Yinghong Shi, Weiren Liu, Xin Zhang, Ao Huang, Jian Zhou, Sheng Wang, Jia Fan, Xiutao Fu, ZhenBin Ding   +15 more
wiley   +1 more source

New perception of mitochondrial regulatory pathway in parkinsonism- ubiquitin, PINK1 and parkin.

Frontiers in Neurology, 2014
Diana Angelika Olszewska, Conor eFearon, Tim eLynch   +2 more
doaj   +1 more source

The role of phospho-ubiquitin in mitochondrial health and diseases. [PDF]

J Biol Chem
Suresh K, Rainville C, Sterner DE, Goldberg MS, Butt TR.   +4 more
europepmc   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Physical exercise as a precision strategy for targeted PINK1 recruitment- a mechanistic review. [PDF]

Front Physiol
Zhu J, Tong L, Thirupathi A.
europepmc   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Parkin regulates NLRP3 degradation through chaperone-mediated autophagy to suppress PANoptosis and protect dopaminergic neurons in Parkinson's disease. [PDF]

J Neuroinflammation
Zheng D, Zhang H, Xie A, Xiao H, Guan D, Xie Z, Luo J, Cao J, Lin T, Xing L, Xia T, Zou F, Chen J.   +12 more
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons. [PDF]

Autophagy Rep
O'Callaghan B, Melandri D, Soltic D, Cosker K, Soutar MPM, Evans JR, Lucas-Clarke H, Robin J, Gandhi S, Birsa N, Arber C, Wray S, Plun-Favreau H.   +12 more
europepmc   +1 more source