Results 141 to 150 of about 44,057 (302)

Recognised in a Quarrel? Positioning of the Child and Parent in Children's and Young People's Stories of Child–Parent Conflicts

Children &Society, EarlyView.
ABSTRACT How children are cared for, how their agentic rights are respected and in what ways they are esteemed as contributors to intergenerational relationships are important questions to consider in child‐related research. Especially in child–parent conflicts, the child's rights and the parent's responsibilities have been argued to be somewhat ...
Maria Lahtinen, Marianne Notko, Eija Salonen, Eija Sevón   +3 more
wiley   +1 more source

Supplementary Material for: Pharmacological or Genetic Activation of Hsp70 Protects against Loss of Parkin Function

, 2016
C.-W. Zhang, Humbert Adeline, Bing‐Han Chai, E.T.E., Hong, Chee H. Ng, Kah‐Leong Lim   +5 more
openalex   +2 more sources

Response to equine cardiac adverse events during sports

Equine Veterinary Education, EarlyView.
Summary Cardiac adverse events and sudden death are a feared scenario for equine veterinarians, with serious consequences for animal health, riders' safety and the social licence to operate equestrian sports. The response to equine cardiac adverse events (CAEs) during sports is poorly defined.
C. Navas de Solis, J. Keen, A. Decloedt, B. Delvescovo, K. Hopster, K. Mitchell, J. Slack, G. van Loon, G. Van Steenkiste, L. Nath   +9 more
wiley   +1 more source

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models

The Journal of Clinical Investigation
Parkinson’s disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The mechanisms underlying these crucial pathological changes remain unclear.
Rui Han, Qi Wang, Xin Xiong, Xiusheng Chen, Zhuchi Tu, Bang Li, Fei Zhang, Chunyu Chen, Mingtian Pan, Ting Xu, Laiqiang Chen, Zhifu Wang, Yanting Liu, Dajian He, Xiangyu Guo, Feng He, Peng Wu, Peng Yin, Yunbo Liu, Xiaoxin Yan, Shihua Li, Xiao-Jiang Li, Weili Yang   +22 more
doaj   +1 more source

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration [PDF]

, 2018
Laura Newman, Gerald S. Shadel
openalex   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

Journal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng, Xiaoping Li, Jialuo Cai, Xinyu Chen, Zelin Xu, Yuntao Luo   +5 more
wiley   +1 more source

Refusing to Listen: Receptive Audiences and the Political Authority of Speech in Hobbes, Locke, and Mill

Constellations, EarlyView.
Thomas Henry Owings
wiley   +1 more source

Institutional Logics and Relational Inequality in UK Surgery: Demographic Dominance and the Uneven Governance of Careers

Journal of Management Studies, EarlyView.
Abstract Persistent gender and racial inequalities within elite professions remain inadequately explained by accounts focusing exclusively on either intra‐organizational processes or field‐level institutional dynamics. Relational inequality theory (RIT) provides a powerful account of closure within organizations but offers limited specification of how ...
Carol Woodhams, Ira Parnerkar
wiley   +1 more source