Results 161 to 170 of about 44,057 (302)

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease [PDF]

open access: bronze, 2013
Donald E. Spratt   +10 more
openalex   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

open access: yesExperimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

open access: yesExperimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak   +3 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney   +4 more
wiley   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese   +5 more
wiley   +1 more source

Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells [PDF]

open access: gold, 2019
Marianna Guida   +12 more
openalex   +1 more source

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