Stimulating proteasomal degradation in human proteinopathies
The FEBS Journal, EarlyView.The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch +2 more
wiley +1 more source
The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in Drosophila disease models. [PDF]
PLoS GenetKatow H, Nguyen T, Park SH, Ryoo HD.
europepmc +1 more source
The Origins of R. G. Collingwood's Philosophy of History in his Philosophy of Religion, 1916–1943
The Heythrop Journal, EarlyView.Abstract This article argues that R.G. Collingwood's philosophy of history was deeply rooted in his early philosophy of religion as expounded in Religion and Philosophy (1916). Although scholars have tended to separate Collingwood's early religious ideas from his later writings, this study demonstrates that his theory of history was informed by his ...
Jacob Donald Chatterjee
wiley +1 more source
Lycopene Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via PINK1/Parkin-Mediated Mitophagy Activation and Apoptosis Attenuation. [PDF]
Antioxidants (Basel)Xu Z +6 more
europepmc +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source
Exercise Stimulates <i>PINK-1, PARKIN, MFN-1</i>, and <i>ATG-3</i> Genes Expression Despite High-fat Diet: Tissue-specific Responses. [PDF]
In VivoDurak S +7 more
europepmc +1 more source
The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases
Immunology &Cell Biology, EarlyView.UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng +3 more
wiley +1 more source
Dapagliflozin attenuates cisplatin-induced nephrotoxicity in rats through modulation of ROS/NF-κB, BCL2/Bax and PINK1/Parkin signaling pathways. [PDF]
Sci RepKhallaf EK +3 more
europepmc +1 more source
Journal of Management Studies, EarlyView.Abstract Persistent gender and racial inequalities within elite professions remain inadequately explained by accounts focusing exclusively on either intra‐organizational processes or field‐level institutional dynamics. Relational inequality theory (RIT) provides a powerful account of closure within organizations but offers limited specification of how ...
Carol Woodhams, Ira Parnerkar
wiley +1 more source
Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast accumulation by inhibiting Parkin-dependent mitophagy. [PDF]
Nat CommunNie Y +13 more
europepmc +1 more source