Results 221 to 230 of about 59,114 (301)

Scotty: lattice coincidences for macromolecular crystallographic phasing

Acta Crystallographica Section D, Volume 82, Issue 7, Page 813-823, July 2026.
Scotty is a tool that leverages Niggli‐cell matches to identify similar crystallographic lattices and perform phasing with difference Fourier methods.When a macromolecular crystal lattice targeted for study is closely related to a previously studied crystal lattice, phasing the target crystal by difference (fast‐)Fourier transform (DFFT) methods is ...
Airlie J. McCoy, Lawrence C. Andrews, Herbert J. Bernstein, Randy J. Read   +3 more
wiley   +1 more source

From homeostasis to pathology, organelle-specific autophagy in skeletal muscle: a PRISMA-ScR scoping review. [PDF]

Front Physiol
Wang C, Liu G, Guo C, Li Q, Wang F, Zhang M.   +5 more
europepmc   +1 more source

Comparative Cochlear–Vestibular Aging Reveals Age‐Aligned Mitochondrial Ultrastructural Burden, Mitophagy–Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline

Aging Cell, Volume 25, Issue 7, July 2026.
This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Jingyi Xie, Xujia Zhang, Jinyi Tian, Yulu Yan, Ke Shi, Yongqi Pan, Yanni Zhang, Zichen Chen, Jianbin Sun, Hui Lv, Jingguo Chen, Xiaoyong Ren, Teru Kamogashira, Xiaotong Zhang, Ying Gao   +14 more
wiley   +1 more source

Mitophagy-activating nanozyme hydrogel for enhanced diabetic wound healing. [PDF]

Mater Today Bio
Zhang J, Tang Z, Zhang X, Zhang H, He W.
europepmc   +1 more source

EGR1 Mediates Ursodeoxycholic Acid‐Promoted Mitophagy to Prevent Postovulatory Aging of Porcine Oocytes

Aging Cell, Volume 25, Issue 7, July 2026.
This study delivers dual key advances: mechanistically, we uncover a novel role of EGR1 as a pivotal transcriptional regulator that bridges upstream gene expression dysregulation to downstream mitophagic decline in oocyte aging; and translationally, we validate the therapeutic potential of the clinical drug UDCA to counteract oocyte aging.
Ying Zhang, Qianru Han, Yongchao Liu, Wei Shen, Shunfeng Cheng, Xiaoya Li   +5 more
wiley   +1 more source

Parkin (PARK2) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Modulation of NFκB Signaling by Natural Compounds in Sarcoma and Normal Muscle Models. [PDF]

Int J Mol Sci
Radzka J, Gizak A, Baczyńska D, Junka A, Dudek B, Brożyna M, Szewczyk A, Kulbacka J.   +7 more
europepmc   +1 more source

Age‐Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age

Aging Cell, Volume 25, Issue 7, July 2026.
Decidual macrophages (DM) in advanced maternal age (AMA) exhibit FOXO3 deficiency‐driven senescence, further accelerated by elevated uterine IL‐6. This manifests as pro‐inflammatory polarization, increased senescence markers, reduced phagocytosis, and impaired trophoblast function.
Yujing Zhang, Yiming Zhang, Guangshun Gong, Zhijing Li, Wenjing Xiong, Xuhui Fang, Ning Lu, Di Wang, Yihui Li, Aihua Liao   +9 more
wiley   +1 more source

Enterovirus-induced cleavage of Mitofusin 2 generates mitophagosomes for enveloped virion release. [PDF]

Sci Adv
Jassey A, Paudel B, Wagner MA, Pollack N, Cheng IT, Godoy-Ruiz R, Weber DJ, Jackson WT.   +7 more
europepmc   +1 more source

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source