Results 221 to 230 of about 44,057 (302)

UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment. [PDF]

Int J Mol Sci
Jin B, Qu J, Xu K, Zhang Y, Xu P, Wang X, Zhao B, Jiao X.   +7 more
europepmc   +1 more source

The mechanism of Parkin activation by PINK1 phosphorylation

, 2019
Christina Gladkova
openalex   +2 more sources

Assessing the Spatiotemporal Variability in Geotechnical Sediment Properties of Beach Cusps on a Sandy Beach

Journal of Geophysical Research: Earth Surface, Volume 131, Issue 5, May 2026.
Abstract This study examined the spatiotemporal variability in geotechnical properties of beach cusp sediments on a sandy beach and tested if such variability can be used for cusp monitoring from satellite imagery. Specifically, sediment properties (including moisture content (w), relative density (Dr), sediment strength (QSBC) and friction angle (ϕ ...
Stephen Adusei, Nina Stark, Jonathan Hubler, Tian‐Jian Hsu   +3 more
wiley   +1 more source

Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies. [PDF]

Cell Death Discov
Wang Z, Lyu Z, Palmen R, Bao Q, Popp F, Dong Q, Bruns CJ, Zhao Y.   +7 more
europepmc   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's disease. [PDF]

Dis Model Mech
Dileep M, Sharma A, Kasturacharya N, Nizami SK, Manjila S, Bhan A, Hasan G.   +6 more
europepmc   +1 more source

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

FAM162A Is a Key Regulator of Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and Longevity

Aging Cell, Volume 25, Issue 5, May 2026.
FAM162A, localized within mitochondrial cristae, emerges as a novel regulator of mitochondrial dynamics. It post‐translationally modulates OPA1, maintaining cristae structure and boosting cellular bioenergetics. This key interaction enhances cell viability, stress resistance, and overall organismal health.
Andrea Matamoros, Juan Pablo Soffia, Marcelo Muñoz, Michael Maturana, Ma Andreina Rangel‐Ramirez, Alvaro Gonzalez‐Ibañez, Gabriela Gómez‐Lillo, Cesar Astorga, Lina M. Ruiz, Ramón A. Jorquera, Alejandra San Martín, Alvaro A. Elorza   +11 more
wiley   +1 more source

Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment. [PDF]

NPJ Aging
Jara C, Venegas-Zamora L, Park-Kang HS, Lira M, Ricca M, Valenzuela S, Tapia-Rojas C.   +6 more
europepmc   +1 more source

Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification

Guanzhi Li, Li Tong, Ye Deng, Xiao Deng, Chao Chen, Bin Yu, Kairui Zhang   +6 more
openalex   +1 more source