Results 211 to 220 of about 59,114 (301)

Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease. [PDF]

Life Sci Alliance
Kopylova IV, Ivanov AB, Eidelman LR, Zaitseva EN, Kulikova ED, Grehnyov DA, Bogomazova AN, Vigont VA, Kaznacheyeva EV, Lagarkova MA, Lebedeva OS, Olekhnovich EI.   +11 more
europepmc   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Deciphering the Neuroautophagic Interactome: Molecular Circuits Linking Selective Autophagy to Neuropathological Cascades in Neurological Disorders. [PDF]

Int J Biol Sci
Luo P, Travis ZD, Lenahan C, Wu H, Zhang J, Yu J, Xu W.   +6 more
europepmc   +1 more source

Renal ultrasound after first febrile urinary tract infection in hospitalized children: The ROUTINE prospective observational study protocol

Journal of Hospital Medicine, Volume 21, Issue 7, Page 828-836, July 2026.
Abstract Background Urinary tract infection (UTI) is a common reason for hospitalization in young children. American and Canadian guidelines recommend universal renal ultrasound after a first febrile UTI to identify genitourinary abnormalities that require further management, despite limited supporting evidence. The Renal ultrasOund after first febrile
Sanjay Mahant, Keenjal Mistry, Ann Bayliss, Nicholas Barrowman, Karen Born, Cornelia Borkhoff, Raman Chawla, David D'Arienzo, Aurelie D'Hondt, Kim De Castris‐Garcia, Joana Dos Santos, Olivier Drouin, Ricardo Faingold, Vince Albert Flores, Jessica Foulds, Jeremy Friedman, Lucy Giglia, Joanna Holland, Radha Jetty, Kristopher Kang, Patricia Li, Grace Leo, Armando Lorenzo, Elise Lu, Colin Macarthur, Kyle Millar, Myla E. Moretti, Nassr Nama, Olivia Ostrow, Rachel Pearl, Patricia Parkin, Mandy Rickard, Mahmoud Sakran, Anupam Sehgal, Nader Shaikh, Sepideh Taheri, Otto G. Vanderkooi, Gemma Vomiero, Kim Zhou, Peter J. Gill, the Canadian Paediatric Inpatient Research Network (PIRN), Maria Karaceper, Alexandra Kilian, Shamini Selvakumar, Matthew Carwana, Karen Forbes, Nassr Nama, Niraj Mistry, Alastair Fung, Geert t'Jong, Gita Wahi, Justin Jagger, Marc‐Andrea Dugas, Paul Moorehead, Karolyn Hardy‐Brown   +54 more
wiley   +1 more source

Mitophagy in kidney and lung epithelial cells: molecular mechanisms, crosstalk, and therapeutic interventions. [PDF]

Front Physiol
Zhou X, Sun J, Miao L, Zhang Y.
europepmc   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Immune Dysregulation in Branched Chain Organic Acidemias

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Organic acidemias (OAs) are a group of inherited disorders, most commonly caused by defects in mitochondrial enzymes involved in amino acid and fatty acid metabolism. While they characteristically present with metabolic and neurological crises, growing evidence reveals a significant burden of chronic immune dysregulation in some disorders and ...
Abdul L. Shakerdi, Jack Drda, Justin A. Dutta, Jerry Vockley   +3 more
wiley   +1 more source

Oxymatrine alleviates cognitive dysfunction in mice caused by chronic cerebral hypoperfusion by promoting SIRT1/ PINK1-mediated mitophagy. [PDF]

Front Pharmacol
Tong B, Li X, Hu W, Ding B, Chen J, Gong J, Gu L, Shi L.   +7 more
europepmc   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Knocking down CLDN7 enhanced the effect of cisplatin in OC cells by regulating mitophagy. [PDF]

J Ovarian Res
Zheng X, Hu B, Xu Q, Wang L, Han B, Wang K.   +5 more
europepmc   +1 more source