Results 201 to 210 of about 44,057 (302)

Nature‐Inspired Surface Modification Strategy Reverses the Autophagic Flux Impairment of Mitochondrial Transplantation for Attenuating Ischemic Strokes

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang, Qiyang Ding, Lei Shi, Ji Xia, Shuyue Zhang, Chenxin Jian, Yixiao Yan, Xiuhua Luo, Jiarui Wang, Ming Cheng, Yiqiong Jia, Hao Tian, Wei Gao   +12 more
wiley   +1 more source

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer. [PDF]

Mol Cell
Hubbi ME, Wang CL, Suhail Y, Almasri NL, Xie J, Hollander EE, Kshitiz, Muir A, Stanger BZ, Dang CV.   +9 more
europepmc   +1 more source

Activation, domains, structures and models of human Parkin.

, 2015
Thomas R. Caulfield, Fabienne C. Fiesel (243606), Elisabeth L. Moussaud-Lamodière (655753), Daniel F. A. R. Dourado (655754), Samuel C. Flores (655755), Wolfdieter Springer   +5 more
openalex   +2 more sources

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Yabanıl tip parkin ifade eden insan nöroblastoma hücrelerinde fosfoproteom analizi

, 2017
MEHIN ZULFIGAROVA
openalex   +1 more source

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

Advanced Science, Volume 13, Issue 26, 8 May 2026.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo, Tao Liu, Hongfei Wang, Qi Gao, Zhaobo Yang, Zumeng Wang, Chenlong Li, Yubing Kang, Kahleong Lim, Wen Liu, Li Lu, Chengwu Zhang   +11 more
wiley   +1 more source

Novel Insights Into the Association Between Parkinson's Disease and Constipation: Role of SHMT2 as a Promising Biomarker

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This study integrated bioinformatics analysis, cellular models, and PD/constipation mouse models to identify SHMT2 as a key shared biomarker linking Parkinson's disease and constipation. SHMT2 upregulation was validated in dopaminergic neurons and the enteric nervous system, highlighting its potential role in gut–brain axis dysfunction.
Jiehua Su, Kaixun Huang, Xiuna Jing, Xiaohuan Liu, Cheng Wen, Rulin Geng, Zhuoying Lai, Zhijia Ruan, Yiqiang Zhan, Danyu Lin, Enxiang Tao   +10 more
wiley   +1 more source

Catchment Influences on Carbon Stable Isotope Variation in Trout; Might It Be Methane?

Ecology and Evolution, Volume 16, Issue 5, May 2026.
Trout stable carbon isotope values vary significantly and appear to relate to catchment characteristics. Low carbon stable isotope values are linked to catchments with low drainage soil and high cover of pasture land use. This is likely to be linked to high levels of methane‐derived carbon entering the stream food web.
Michael Hinchliffe, Aimeric Blaud, Peter Gilbert, Rona McGill, Kenny Galt, Robert A. Briers   +5 more
wiley   +1 more source

Topography, management, and extreme precipitation influence greenhouse gas emissions in a cool, humid corn silage system

Journal of Environmental Quality, Volume 55, Issue 3, May/June 2026.
Abstract Agricultural soils are sources of nitrous oxide (N2O) and, under prolonged saturation, methane (CH4)—two potent greenhouse gases (GHGs). Soil management, field topography, and climate all influence GHG emissions, yet their interactions are not well understood.
Molly Ratliff, Joshua W. Faulkner, Eric D. Roy, Marie English, Dan Liptzin, Reza K. Afshar, E. Carol Adair   +6 more
wiley   +1 more source

Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada

Journal of Hospital Medicine, Volume 21, Issue 5, Page 495-505, May 2026.
Abstract Background and Objectives Children with medical complexity (CMC) have chronic health conditions often associated with functional limitations. CMC comprise 1%–5% of the pediatric population. In Canada, their care accounts for one‐third of pediatric health spending.
Erin Hessey, Thaksha Thavam, Sanjay Mahant, Eyal Cohen, Jingqin Zhu, Francine Buchanan, Teresa To, Peter J. Gill, Ontario Pediatric Hospital Care Study Group (OPHCSG) and the Canadian Paediatric Inpatient Research Network (PIRN), Wenjia Chen, Ronald Cohn, Mairead Green, Matt Hall, Kate Langrish, Colin Macarthur, Myla Moretti, Patricia Parkin, Michelle Quinlan, Ann Bayliss, Ronik Kanani, Sean Murray, Catherine Pound, Mahmoud Sakran, Anupam Sehgal, Sepi Taheri, Gita Wahi   +25 more
wiley   +1 more source