Results 191 to 200 of about 59,114 (301)

Mitophagy in ophthalmic pathologies: Molecular mechanisms and therapeutic implications. [PDF]

Medicine (Baltimore)
Han Y, Feng J, Gong X, Tang G, Yin Y, Li J, Liu Y, Zhang J, Song J, Bi H.   +9 more
europepmc   +1 more source

Impairments in mitochondrial dynamics and morphology in skeletal muscle of breast cancer patients after a single paclitaxel administration

Experimental Physiology, EarlyView.
Abstract Standard chemotherapy regimens for patients with breast cancer are based on epirubicin–cyclophosphamide (EC) and paclitaxel (TAX) administrations. While it has been shown that first EC administration impairs mitochondrial homeostasis, the isolated effects of TAX have not been studied without previous chemotherapy exposure.
Joris Mallard, Elyse Hucteau, Laura Somme, Hervé Bischoff, Valérie Demais, Pauline Silvestrin, Anne‐Laure Charles, Roland Schott, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano   +10 more
wiley   +1 more source

PTEN modulates mitochondrial dysfunction in podocytes via the PINK1/Parkin signal pathway. [PDF]

Transl Pediatr
Ren Q, Yu S.
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

DAPK1-Mediated Parkin Inactivation Enhances Neurotoxicity via MITOL-Dependent Degradation. [PDF]

J Cell Mol Med
Park CH, Shin D, Chung KC.
europepmc   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Natural Product Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease: Targeted Mitochondrial Quality Control. [PDF]

Drug Des Devel Ther
Liu J, Li F, Zeng Q, Hu W, Yang L, Luo S, Lv F, Li D, Deng Y.   +8 more
europepmc   +1 more source

A high‐fat, high‐sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin‐deficient mice

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald, Swathy Krishna, Ji Heun Lee, Melissa Roths, Rudy J. Valentine, Joshua T. Selsby   +5 more
wiley   +1 more source

The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in Drosophila disease models. [PDF]

PLoS Genet
Katow H, Nguyen T, Park SH, Ryoo HD.
europepmc   +1 more source

Tillage does not impact soil greenhouse gas emissions in a Central Texas rainfed maize–cotton system

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Agricultural soils are a significant source of greenhouse gas (GHG) emissions, primarily as N2O. Monitoring how management practices impact soil gas fluxes (CO2, CH4, and N2O) is useful for making sure conservation practices (e.g., no‐till) are sustainable with regards to all potential environmental impacts.
Dorothy Menefee, Hal Collins, Doug Smith
wiley   +1 more source