Results 71 to 80 of about 125,678 (274)

Dual tasking in Parkinson's disease: cognitive consequences while walking [PDF]

, 2017
Published in final edited form as: Neuropsychology. 2017 September; 31(6): 613–623. doi:10.1037/neu0000331.OBJECTIVE: Cognitive deficits are common in Parkinson's disease (PD) and exacerbate the functional limitations imposed by PD's hallmark motor ...
Barthelemy, Olivier J., Cronin-Golomb, Alice, Ellis, Terry D., Neargarder, Sandy, Ren, Xiaolin, Salazar, Robert D., Toraif, Noor   +6 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease [PDF]

, 2016
Recent research highlights the association of gait and cognition in older adults but a stronger understanding is needed to discern coincident pathophysiology, patterns of change, examine underlying mechanisms and aid diagnosis.
Bunce, Jennifer, Burn, David, Lord, Sue, Morris, Rosie, Rochester, Lynn   +4 more
core   +2 more sources

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Risk of dementia and Parkinson's disease in patients treated with androgen deprivation therapy using gonadotropin-releasing hormone agonist for prostate cancer: A nationwide population-based cohort study.

PLoS ONE, 2020
Recent studies reported conflicting results on the association of androgen deprivation therapy (ADT) with dementia and Parkinson's disease in patients with prostate cancer (Pca).
Myungsun Shim, Woo Jin Bang, Cheol Young Oh, Yong Seong Lee, Seong Soo Jeon, Hanjong Ahn, Young-Su Ju, Jin Seon Cho   +7 more
doaj   +1 more source

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]

, 2015
BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott, Mante, Michael, Masliah, Eliezer, Rockenstein, Edward, Valera, Elvira   +4 more
core   +2 more sources

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Parkinson’s disease – a frequent cause of dementia

Journal of Education, Health and Sport
Introduction and Purpose. Parkinson's disease (PD) is a progressive neurodegenerative disorder with characteristic motor symptoms and often overlooked non-motor manifestations, including dementia.
Marta Wardęszkiewicz, Szymon Markowiak, Wiktoria Jabłońska, Amelia Kasprzak, Maciej Świercz, Monika Truchta, Aleksandra Mańkowska, Agata Kolano, Anna Pejas   +8 more
doaj   +1 more source

Neural correlates of early cognitive dysfunction in Parkinson's disease

Annals of Clinical and Translational Neurology, 2019
Objective Dementia is a common and feared aspect of Parkinson's disease but there are no robust predictors of cognitive outcome. Visuoperceptual deficits are linked to risk of dementia in Parkinson's disease but whether they predict cognitive change is ...
Rimona S. Weil, Joel S. Winston, Louise‐Ann Leyland, Katerina Pappa, Ribeya B. Mahmood, Huw R. Morris, Geraint Rees   +6 more
doaj   +1 more source

Neuropsychiatric disturbances in atypical Parkinsonian disorders [PDF]

, 2018
Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are the most common atypical parkinsonisms. These disorders are characterized by varying combinations of autonomic, cerebellar and pyramidal system ...
Belvisi, Daniele, Berardelli, Isabella, Fabbrini, Andrea, Fabbrini, Giovanni, Pasquini, Massimo, Pompili, Maurizio, Suppa, Antonio   +6 more
core   +1 more source