Results 201 to 210 of about 442,406 (307)

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Correction to "Beyond Infections: A Case Report on the Identification of Neuroleptic Malignant Syndrome (NMS) in a Complex Clinical Context". [PDF]

Clin Case Rep
europepmc   +1 more source

User Experiences of Limb-Worn Wearable Devices for Monitoring Parkinson Disease Motor Function and Blood Pressure: Usability Study. [PDF]

JMIR Form Res
Kenny L, Sica M, Crowe C, O'Mahony L, O'Flynn B, Mueller DS, Tedesco S, Barton J, Timmons S.   +8 more
europepmc   +1 more source

[Parkinson's disease and parkinsonism].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2017
Kashif Waqar, Faiz, Lasse, Pihlstrøm
openaire   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Ultrastructural and chemical analysis of human Locus coeruleus using correlative microscopy and mass spectrometry [PDF]

BIO Web of Conferences
Berro Zahraa, Subirana Maria Angels, Warres Clementine, Wirtz Tom, Taubitz Tatjana, Audinot Jean-Nicolas, Zucca Fabio A., Mittelbronn Michel, Zecca Luigi, Biesemeier Antje   +9 more
doaj   +1 more source

Home-Based Augmented Reality Exercise For People With Parkinson Disease: Qualitative Acceptability Study. [PDF]

JMIR Rehabil Assist Technol
Hardeman LES, van Benten E, Hoogendoorn EM, van Gameren M, Nonnekes J, Roerdink M, Geerse DJ.   +6 more
europepmc   +1 more source

Five times sit-to-stand test performance in Parkinson\u27s disease [PDF]

, 2011
Duncan, Ryan P, Earhart, Gammon M, Leddy, Abigail L   +2 more
core   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Parkinson disease treatments on national essential medicines lists, African Region. [PDF]

Bull World Health Organ
Fothergill-Misbah N, Cataldi R, Stothard M, Chowdhary N, Okubadejo N, Cappello B, Walker R, Dua T.   +7 more
europepmc   +1 more source