No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial. [PDF]
PLoS ONE, 2014 Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease.
Chizoba C Umeh +10 more
doaj +11 more sources
Role of mitochondria in Parkinson disease [PDF]
, 1999 The cause of the selective degeneration of nigrostriatal neurons in Parkinson disease (PD) has remained largely unknown. Exceptions include rare missense mutations in the alpha-synuclein gene on chromosome 4, a potentially pathogenic mutation affecting ...
Graeber, M. B. +4 more
core +2 more sources
Stability of MDS-UPDRS Motor Subtypes Over Three Years in Early Parkinson's Disease
Frontiers in Neurology, 2021 Background: Various classifications have been proposed to subtype Parkinson's disease (PD) based on their motor phenotypes. However, the stability of these subtypes has not been properly evaluated.Objective: The goal of this study was to understand the ...
Abhijeet K. Kohat +33 more
doaj +1 more source
Is restless legs syndrome in Parkinson disease patients associated with any specific factor? [PDF]
Arquivos de Neuro-Psiquiatria, 2021 Background: Restless legs syndrome or Willis-Ekbom disease is a disorder characterized by unpleasant sensations associated with the need to mobilize the lower limbs.
Manoel Alves SOBREIRA-NETO +7 more
doaj +1 more source
Inflammation and immune dysfunction in Parkinson disease
Nature reviews. Immunology, 2022 Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology. Neurohistological and neuroimaging studies
M. Tansey +5 more
semanticscholar +1 more source
Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
Scientific Reports, 2023 A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID).
Ninfa Amato +5 more
doaj +1 more source
Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease
Nature Communications, 2023 Little is known about circular RNAs (circRNAs) in specific brain cells and human neuropsychiatric disease. Here, we systematically identify over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains ...
Xianjun Dong +11 more
doaj +1 more source
Patient-Centric Care for Parkinson's Disease: From Hospital to the Community
Frontiers in Neurology, 2020 Parkinson's disease (PD) is a chronic neurodegenerative disease with complex motor and non-motor symptoms often leading to significant caregiver burden.
Yin Minn Aye +27 more
doaj +1 more source
Diseases of the nervous system, 2020 Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand.
Harald Sontheimer
semanticscholar +1 more source
Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
npj Parkinson's Disease, 2023 The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression ...
Marta Soto +17 more
doaj +1 more source