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The Lancet, 2021 Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause.
Bloem, B.R., Okun, M.S., Klein, C.
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The Lancet, 2004 Parkinson's disease is the most common serious movement disorder in the world, affecting about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons in the substantia nigra, and its cause is enigmatic in most individuals.
Samii, Ali +2 more
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Familial Parkinson’s Disease/Parkinsonism [PDF]
BioMed Research International, 2015 Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD.
Hiroyuki Tomiyama +3 more
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Annals of Indian Academy of Neurology, 2011 These guidelines present evidence for interventions to manage early stage, uncomplicated Parkinson's Disease. This includes pharmacological and non-pharmacological interventions. The evidence for pharmacological agents to provide neuroprotection or disease modification, such as a delay in disease progression, is discussed, with no trials demonstrating ...
Behari, Madhuri +11 more
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Parkinson’s Disease and Autophagy [PDF]
Parkinson's Disease, 2012 It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result in the accumulation of aggregate-prone proteins and subsequent neurodegeneration.
Ana María Sánchez-Pérez +5 more
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The heterogeneity of Parkinson’s disease
Journal of Neural Transmission, 2023 AbstractThe heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design.
Ullrich Wüllner +7 more
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Acta clinica Croatica, 2009 Enteropathogenesis and clinical picture of PD- minireview.
Demarin, Vida +6 more
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Noradrenaline and Parkinson's Disease [PDF]
Frontiers in Systems Neuroscience, 2011 Parkinson's disease (PD) is characterized by the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta, and motor symptoms including bradykinesia, rigidity, and tremor at rest. These symptoms are exhibited when striatal dopamine concentration has decreased by around 70%.
Claire eDelaville +3 more
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Methamphetamine and Parkinson's Disease [PDF]
Parkinson's Disease, 2013 Parkinson's disease (PD) is a neurodegenerative disorder predominantly affecting the elderly. The aetiology of the disease is not known, but age and environmental factors play an important role. Although more than a dozen gene mutations associated with familial forms of Parkinson's disease have been described, fewer than 10% of all cases can be ...
Rosario Moratalla +6 more
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Imaging in Parkinson's Disease [PDF]
Clinical Medicine, 2016 Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the loss of nigrostriatal dopaminergic neurons and aggregation of misfolded α-synuclein in Lewy bodies. The underlying mechanisms of neurodegeneration in PD are still unknown, and there are no disease-modifying treatments to slow the neurodegenerative processes.
Politis, Marios +2 more
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