Results 11 to 20 of about 119,702 (338)
A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022 Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song +11 more
wiley +1 more source
Annals of Indian Academy of Neurology, 2011 These guidelines present evidence for interventions to manage early stage, uncomplicated Parkinson's Disease. This includes pharmacological and non-pharmacological interventions. The evidence for pharmacological agents to provide neuroprotection or disease modification, such as a delay in disease progression, is discussed, with no trials demonstrating ...
Behari, Madhuri +11 more
openaire +8 more sources
Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
npj Parkinson's Disease, 2023 The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression ...
Marta Soto +17 more
doaj +1 more source
Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
npj Parkinson's Disease, 2021 Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the ...
Rubén Fernández-Santiago +9 more
doaj +1 more source
Deep Learning Predicts Prevalent and Incident Parkinson's Disease From UK Biobank Fundus Imaging [PDF]
, 2023 Parkinson's disease is the world's fastest-growing neurological disorder. Research to elucidate the mechanisms of Parkinson's disease and automate diagnostics would greatly improve the treatment of patients with Parkinson's disease. Current diagnostic methods are expensive and have limited availability.
arxiv +1 more source
npj Parkinson's Disease, 2022 The assessment of cognitive deficits is pivotal for diagnosis and management in patients with parkinsonisms. Low levels of correspondence are observed between evaluations assessed with screening cognitive tests in comparison with those assessed with in ...
Paola Ortelli +15 more
doaj +1 more source
Microbiota Dysbiosis in Parkinson Disease—In Search of a Biomarker
Biomedicines, 2022 Numerous studies have highlighted the role of the gastrointestinal system in Parkinson disease pathogenesis. It is likely triggered by proinflammatory markers produced by specific gut bacteria. This review’s aim is to identify gut bacterial biomarkers of
Julia Maya Nowak +4 more
doaj +1 more source
No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial. [PDF]
PLoS ONE, 2014 Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease.
Chizoba C Umeh +10 more
doaj +1 more source
Noradrenaline and Parkinson's Disease [PDF]
Frontiers in Systems Neuroscience, 2011 Parkinson's disease (PD) is characterized by the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta, and motor symptoms including bradykinesia, rigidity, and tremor at rest. These symptoms are exhibited when striatal dopamine concentration has decreased by around 70%.
Claire eDelaville +3 more
openaire +5 more sources
Parkinson’s Disease and Autophagy [PDF]
Parkinson's Disease, 2012 It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result in the accumulation of aggregate-prone proteins and subsequent neurodegeneration.
Ana María Sánchez-Pérez +5 more
openaire +5 more sources