Results 11 to 20 of about 90,745 (249)
Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
npj Parkinson's Disease, 2023 The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression ...
Marta Soto +17 more
doaj +1 more source
Frontiers in Immunology, 2023 Epigenetic reprogramming is the ability of innate immune cells to form memories of environmental stimuli (priming), allowing for heightened responses to secondary stressors.
Minhong Huang +11 more
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Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
npj Parkinson's Disease, 2021 Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the ...
Rubén Fernández-Santiago +9 more
doaj +1 more source
No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial. [PDF]
PLoS ONE, 2014 Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease.
Chizoba C Umeh +10 more
doaj +1 more source
npj Parkinson's Disease, 2022 The assessment of cognitive deficits is pivotal for diagnosis and management in patients with parkinsonisms. Low levels of correspondence are observed between evaluations assessed with screening cognitive tests in comparison with those assessed with in ...
Paola Ortelli +15 more
doaj +1 more source
Microbiota Dysbiosis in Parkinson Disease—In Search of a Biomarker
Biomedicines, 2022 Numerous studies have highlighted the role of the gastrointestinal system in Parkinson disease pathogenesis. It is likely triggered by proinflammatory markers produced by specific gut bacteria. This review’s aim is to identify gut bacterial biomarkers of
Julia Maya Nowak +4 more
doaj +1 more source
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Neurobiology of Disease, 2008 The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important cellular mechanisms for protein degradation.
Tianhong Pan +5 more
doaj +1 more source
Frontiers in Neurology, 2018 BackgroundAlthough bedrooms are identified as a major location for accidents among Parkinson’s disease (PD) patients, there are no studies that specifically evaluate the bedroom environments of PD patients.ObjectiveTo examine the physical bedroom ...
Roongroj Bhidayasiri +11 more
doaj +1 more source
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. [PDF]
PLoS Biology, 2018 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the
Farah H Bardai +5 more
doaj +1 more source