Results 11 to 20 of about 9,643,208 (350)
Patient-Centric Care for Parkinson's Disease: From Hospital to the Community
Frontiers in Neurology, 2020 Parkinson's disease (PD) is a chronic neurodegenerative disease with complex motor and non-motor symptoms often leading to significant caregiver burden.
Yin Minn Aye +27 more
doaj +1 more source
Incidence of Parkinson disease in North America
npj Parkinson's Disease, 2022 Parkinson disease (PD) is the second most common age-related neurodegenerative condition diagnosed in North America. We recently demonstrated, using multiple epidemiological data sources, that the prevalence of PD diagnoses was greater than previously ...
A. Willis +16 more
semanticscholar +1 more source
Diseases of the nervous system, 2020 Often the first symptom of Parkinson disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand.
Harald Sontheimer
semanticscholar +1 more source
Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
npj Parkinson's Disease, 2023 The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression ...
Marta Soto +17 more
doaj +1 more source
Frontiers in Immunology, 2023 Epigenetic reprogramming is the ability of innate immune cells to form memories of environmental stimuli (priming), allowing for heightened responses to secondary stressors.
Minhong Huang +11 more
doaj +1 more source
Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
npj Parkinson's Disease, 2021 Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the ...
Rubén Fernández-Santiago +9 more
doaj +1 more source
npj Parkinson's Disease, 2022 The assessment of cognitive deficits is pivotal for diagnosis and management in patients with parkinsonisms. Low levels of correspondence are observed between evaluations assessed with screening cognitive tests in comparison with those assessed with in ...
Paola Ortelli +15 more
doaj +1 more source
Immunosuppressants and risk of Parkinson disease [PDF]
, 2018 We performed a population-based case-control study of United States Medicare beneficiaries age 60-90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use ...
Camacho-Soto, Alejandra +5 more
core +2 more sources
Microbiota Dysbiosis in Parkinson Disease—In Search of a Biomarker
Biomedicines, 2022 Numerous studies have highlighted the role of the gastrointestinal system in Parkinson disease pathogenesis. It is likely triggered by proinflammatory markers produced by specific gut bacteria. This review’s aim is to identify gut bacterial biomarkers of
Julia Maya Nowak +4 more
doaj +1 more source
Superoxide Dismutase (SOD)-mimetic M40403 is protective in cell and fly models of paraquat toxicity: Implications for Parkinson disease [PDF]
, 2016 Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting 3c1-2% of people over 65 years of age. Oxidative damage is considered to play a central role in the progression of Parkinson disease and strong evidence links chronic
Beltramini, Mariano +8 more
core +1 more source