Results 41 to 50 of about 274,716 (345)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Measuring the Burden of Hospitalization in Patients with Parkinson´s Disease in Spain.

PLoS ONE, 2016
IntroductionThis epidemiological survey estimates the hospitalization burden related to Parkinson´s Disease in Spain.MethodsThis observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data ...
Ruth Gil-Prieto, Raquel Pascual-Garcia, Jesus San-Roman-Montero, Pablo Martinez-Martin, Javier Castrodeza-Sanz, Angel Gil-de-Miguel   +5 more
doaj   +1 more source

Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease

Annals of Clinical and Translational Neurology, 2020
Objective To determine the evolution of numerous neuropsychiatric symptoms and cognitive abilities in Parkinson disease from disease onset. Methods Prospectively collected, longitudinal (untreated, disease onset to year 5), observational data from ...
Daniel Weintraub, Chelsea Caspell‐Garcia, Tanya Simuni, Hyunkeun R. Cho, Christopher S. Coffey, Dag Aarsland, Roy N. Alcalay, Matthew J. Barrett, Lana M. Chahine, Jamie Eberling, Alberto J. Espay, Jamie Hamilton, Keith A. Hawkins, James Leverenz, Irene Litvan, Irene Richard, Liana S. Rosenthal, Andrew Siderowf, Michele York, Parkinson’s Progression Markers Initiative   +19 more
doaj   +1 more source

PHEN : parkinson helper emergency notification system using Bayesian Belief Network [PDF]

, 2015
Context-aware systems are used to aid users in their daily lives. In the recent years, researchers are exploring how context aware systems can benefit humanity through assist patients, specifically those who suffer incurable diseases, to cope with their ...
Khreiss, Malak, Mcheick, Hamid, Sweidan, Hala, Zaarour, Iyad   +3 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Microglia depletion reduces neurodegeneration and remodels extracellular matrix in a mouse Parkinson’s disease model triggered by α-synuclein overexpression

npj Parkinson's Disease
Chronic neuroinflammation with sustained microglial activation occurs in Parkinson’s disease (PD), yet the mechanisms and exact contribution of these cells to the neurodegeneration remains poorly understood.
Zhen Zhang, Kun Niu, Taoying Huang, Jiali Guo, Gongbikai Xarbat, Xiaoli Gong, Yunke Gao, Feiyang Liu, Shan Cheng, Wenting Su, Fei Yang, Zhaoyuan Liu, Florent Ginhoux, Ting Zhang   +13 more
doaj   +1 more source

Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson’s Disease

Gastroenterology Research and Practice, 2015
The diagnosis of Parkinson’s disease (PD) relies on clinical features whereas pathological confirmation is only possible with autopsy examination. The neuropathological hallmarks of PD are neuronal loss and the presence of inclusions termed Lewy bodies ...
Maria Graciela Cersosimo
doaj   +1 more source

A smart tool for the diagnosis of Parkinsonian syndrome using wireless watches [PDF]

, 2014
This work is licensed under a Creative Commons Attribution 3.0 License.Early detection and diagnosis of Parkinson disease will provide a good chance for patients to take early actions and prevent its further development.
Goll, A, Meng, H
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Verbascoside promotes the regeneration of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra

Neural Regeneration Research, 2016
Tyrosine hydroxylase is a key enzyme in dopamine biosynthesis. Change in tyrosine hydroxylase expression in the nigrostriatal system is closely related to the occurrence and development of Parkinson′s disease.
Jian-qing Liang, Li Wang, Jian-cheng He, Xian-dong Hua   +3 more
doaj   +1 more source