Results 61 to 70 of about 9,346,254 (401)
Neural Regeneration Research, 2016 Tyrosine hydroxylase is a key enzyme in dopamine biosynthesis. Change in tyrosine hydroxylase expression in the nigrostriatal system is closely related to the occurrence and development of Parkinson′s disease.
Jian-qing Liang +3 more
doaj +1 more source
Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease
Annals of Clinical and Translational Neurology, 2020 Objective To determine the evolution of numerous neuropsychiatric symptoms and cognitive abilities in Parkinson disease from disease onset. Methods Prospectively collected, longitudinal (untreated, disease onset to year 5), observational data from ...
Daniel Weintraub +19 more
doaj +1 more source
Molecular Neurodegeneration, 2020 That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson’s disease is a widely appreciated but poorly understood phenomenon.
Preston Ge, V. Dawson, T. Dawson
semanticscholar +1 more source
Earthing effects on mitochondrial function: ATP production and ROS generation
FEBS Open Bio, EarlyView.In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley +1 more source
Glucocerebrosidase and its relevance to Parkinson disease
Molecular Neurodegeneration, 2019 Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are among the most common known genetic risk factors for the development of Parkinson disease and related synucleinopathies.
Jenny Do +3 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra +17 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede +3 more
wiley +1 more source
A novel method for evaluating brain function and microstructural changes in Parkinson′s disease
Neural Regeneration Research, 2015 In this study, microstructural brain damage in Parkinson′s disease patients was examined using diffusion tensor imaging and tract-based spatial statistics.
Ming-fang Jiang +4 more
doaj +1 more source
CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad +7 more
wiley +1 more source
The role of the brain renin-angiotensin system in Parkinson´s disease
Translational NeurodegenerationThe renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS.
Jose Luis Labandeira-Garcia +3 more
doaj +1 more source