Results 1 to 10 of about 121,271 (310)
Familial Parkinson’s Disease/Parkinsonism [PDF]
BioMed Research International, 2015 Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD.
Hiroyuki Tomiyama +3 more
openaire +2 more sources
Journal of Neuroinflammation, 2023 Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1.
Max Stevenson +7 more
doaj +1 more source
Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection
PLoS Neglected Tropical Diseases, 2022 Dengue virus (DENV) is a flavivirus that is a significant cause of human disease costing billions of dollars per year in medical and mosquito control costs. It is estimated that up to 20% of DENV infections affect the brain.
Hannah K. Hopkins +2 more
doaj +2 more sources
Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Bosutinib, a dual Abelson/Src inhibitor, was investigated in individuals with dementia with Lewy bodies (DLB). Methods A single site, randomized, double‐blind, placebo‐controlled study of the effects of oral bosutinib, 100 mg once daily for ...
Fernando L. Pagan +8 more
doaj +1 more source
Progress on diagnosis and treatment of functional parkinsonism
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Functional parkinsonism (FP) is a disorder caused by psychological factors rather than neurodegeneration. Functional parkinsonism has a great influence on patients' quality of life and daily function. However, due to overlapping with some of the symptoms
HUANG Pei, WANG Gang
doaj +1 more source
Sleep Disorders in Early-Onset Parkinsonism: A Population-Based Study
Journal of Parkinson’s Disease, 2023 Background: Sleep disturbances are common in parkinsonian disorders; however, whether sleep disorders affect individuals with early-onset parkinsonism and whether they differ from individuals with typical-onset parkinsonism is unknown.
Stuart J. McCarter +7 more
doaj +1 more source
Early-Onset Parkinsonism and Early-Onset Parkinson’s Disease: A Population-Based Study (2010-2015)
Journal of Parkinson’s Disease, 2021 Background: Early-onset Parkinson’s disease (EOPD), occurring between ages 40 and 55, carries social, societal, and personal consequences and may progress, with fewer comorbidities than typical, later-onset disease.
Emanuele Camerucci +9 more
doaj +1 more source
Brain and Behavior, 2023 Introduction Secondary tumoral parkinsonism is a rare phenomenon that develops as a direct or indirect result of brain neoplasms or related conditions.
Gustav Cedergren Weber +4 more
doaj +1 more source
The Lancet, 2021 Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause.
Bloem, B.R., Okun, M.S., Klein, C.
openaire +2 more sources
Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells
Disease Models & Mechanisms, 2016 X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito +12 more
doaj +1 more source