Results 11 to 20 of about 109,533 (316)
Drugs in R&D, 2019 Background and objectives Inhibition of Abelson (Abl) tyrosine kinase as a therapeutic target has been gaining attention in neurodegeneration. Post-mortem Alzheimer’s and Parkinson’s disease brains show that the levels of several other tyrosine kinases ...
Alan J. Fowler +7 more
doaj +1 more source
The Current State of Parkinsonism in West Africa: A Systematic Review
Parkinson's Disease, 2021 Parkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism.
Jude T. Quarshie +3 more
doaj +1 more source
Study on drug-induced parkinsonism and its clinical patterns in Eastern Indian population
APIK Journal of Internal Medicine, 2023 Background: Drug-induced parkinsonism (DIP) is important as it is reversible if identified and treated early. We present herewith various clinical patterns and drugs commonly causing DIP.
Praveen Kumar Yadav
doaj +1 more source
EMBO Molecular Medicine, 2013 Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β‐amyloid (plaques) and hyper‐phosphorylated Tau (tangles).
Irina Lonskaya +4 more
doaj +1 more source
X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B
Neurobiology of Disease, 2017 X-linked Dystonia-Parkinsonism (XDP) is a progressive neurodegenerative disease involving the loss of medium spiny neurons within the striatum. An XDP-specific haplotype has been identified, consisting of seven sequence variants which cluster around the ...
Christine A. Vaine +7 more
doaj +1 more source
Neurobiology of Disease, 2020 Neuroinflammation plays a pathogenic role in neurodegenerative diseases and recent findings suggest that it may also be involved in X-linked Dystonia-Parkinsonism (XDP) pathogenesis.
Tiziana Petrozziello +16 more
doaj +1 more source
Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.
PLoS ONE, 2021 BackgroundMobility disability and parkinsonism are associated with decreased survival in older adults. This study examined the transition from no motor impairment to mobility disability and parkinsonism and their associations with death.Methods867 ...
Shahram Oveisgharan +3 more
doaj +1 more source
Total daily physical activity, brain pathologies, and parkinsonism in older adults.
PLoS ONE, 2020 ObjectiveWe examined the association of physical activity, postmortem brain pathologies, and parkinsonism proximate to death in older adults.MethodsWe studied the brains of 447 older decedents participating in a clinical-autopsy cohort study. We deployed
Shahram Oveisgharan +6 more
doaj +1 more source
Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism
Parkinson's Disease, 2022 Introduction. Brain SPECT with 99mTc-TRODAT-1 (SPECT-TRODAT) may be a useful tool in the differential diagnosis of Parkinsonism. Objective. To compare results of SPECT-TRODAT with clinical findings in patients with Parkinsonism. Methods. We evaluated 153
Giorgio Fabiani +4 more
doaj +1 more source
Case Report: Progressive Asymmetric Parkinsonism Secondary to CADASIL Without Dementia
Frontiers in Neurology, 2022 Parkinsonism is a rare phenotype of cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL), all of which involve cognitive decline. Normal cognition has not been reported in previous disease studies.
Weihang Guo +23 more
doaj +1 more source