Results 11 to 20 of about 121,271 (310)
BMC Neurology, 2005 Background parkin mutations are a common cause of parkinsonism. Possessing two parkin mutations leads to early-onset parkinsonism, while having one mutation may predispose to late-onset disease.
Schellenberg Gerard D +5 more
doaj +4 more sources
Low dose of Rotigotine in post-stroke patients with vascular parkinsonism and obstructive sleep apnoea syndrome, effects on quality of life and rehabilitation therapy [PDF]
, 2017 Stroke is a frequent cause of disability in U.S.A. (200.000/ year). Aim: The aim of this study is to underline the effect of low dose of Rotigotine patches 2 mg/24 h, a complete dopamine agonist with continuous dopaminergic stimulation through the ...
Ceratti U +7 more
core +1 more source
Drugs in R&D, 2019 Background and objectives Inhibition of Abelson (Abl) tyrosine kinase as a therapeutic target has been gaining attention in neurodegeneration. Post-mortem Alzheimer’s and Parkinson’s disease brains show that the levels of several other tyrosine kinases ...
Alan J. Fowler +7 more
doaj +1 more source
New Perspective on Parkinsonism in Frontotemporal Lobar Degeneration [PDF]
Journal of Movement Disorders, 2013 Frontotemporal dementia (FTD) is the second most common type of presenile dementia. Three clinical prototypes have been defined; behavioral variant FTD, semantic dementia, and progressive nonfluent aphasia.
Hee Kyung Park, Sun J. Chung
doaj +1 more source
Atypical parkinsonism: An Update. [PDF]
, 2013 Purpose of review: This update discusses novel aspects on genetics, diagnosis, and treatments of atypical parkinsonism published over the past 2 years. Recent findings: A genome-wide association study identified new genetic risk factors for progressive ...
Hoeglinger, GU, Stamelou, M
core +1 more source
Altered resting state brain metabolic connectivity in dementia with Lewy bodies
Frontiers in Neurology, 2022 Although dementia with Lewy bodies (DLB) have Parkinsonism in common with Parkinson's disease (PD) or PD dementia (PDD), they have different neuropathologies that underlie Parkinsonism.
Euna Choi +11 more
doaj +1 more source
Environmental Exposures and Parkinson's Disease. [PDF]
, 2016 Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
core +2 more sources
EMBO Molecular Medicine, 2013 Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β‐amyloid (plaques) and hyper‐phosphorylated Tau (tangles).
Irina Lonskaya +4 more
doaj +1 more source
X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B
Neurobiology of Disease, 2017 X-linked Dystonia-Parkinsonism (XDP) is a progressive neurodegenerative disease involving the loss of medium spiny neurons within the striatum. An XDP-specific haplotype has been identified, consisting of seven sequence variants which cluster around the ...
Christine A. Vaine +7 more
doaj +1 more source
The Current State of Parkinsonism in West Africa: A Systematic Review
Parkinson's Disease, 2021 Parkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism.
Jude T. Quarshie +3 more
doaj +1 more source