Environmental Exposures and Parkinson's Disease. [PDF]
, 2016 Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
core +2 more sources
Parkinson's Disease and Parkinsonism: Neuropathology [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy.
openaire +3 more sources
Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases [PDF]
, 2017 Objective: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients.
, +13 more
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Neuroimaging in Functional Movement Disorders. [PDF]
, 2019 PURPOSE OF REVIEW: Functional movement disorders are common and disabling causes of abnormal movement control. Here, we review the current state of the evidence on the use of neuroimaging in Functional movement disorders, particularly its role in helping
Edwards, MJ, Roelofs, JJ, Teodoro, T
core +2 more sources
Drug-induced parkinsonism: what should a psychiatrist know?
Revista Mexicana de Neurociencia, 2021 Drug-induced parkinsonism is the main cause of secondary parkinsonism in the world. Antipsychotics, antidepressants, and mood stabilizers are the most common drugs implicated in the parkinsonism.
Santiago Vásquez-Builes +4 more
doaj +1 more source
Simulation Study and At Home Diagnostic Tool for Early Detection of Parkinsons Disease [PDF]
arXiv, 2021 Hypomimia is a condition in the early stages of the progression of Parkinsons disease that limits the movement of facial muscles, restricting the accurate depiction of facial expressions. Also known as facial masking, this condition is an early symptom of Parkinson's disease, a neurodegenerative disorder that affects movement. To date, no specific test
arxiv
Vision-Based Assessment of Parkinsonism and Levodopa-Induced Dyskinesia with Deep Learning Pose Estimation [PDF]
Journal of NeuroEngineering and Rehabilitation (2018) 15:97, 2017 Objective: To apply deep learning pose estimation algorithms for vision-based assessment of parkinsonism and levodopa-induced dyskinesia (LID). Methods: Nine participants with Parkinson's disease (PD) and LID completed a levodopa infusion protocol, where symptoms were assessed at regular intervals using the Unified Dyskinesia Rating Scale (UDysRS) and ...
arxiv +1 more source
Total daily physical activity, brain pathologies, and parkinsonism in older adults.
PLoS ONE, 2020 ObjectiveWe examined the association of physical activity, postmortem brain pathologies, and parkinsonism proximate to death in older adults.MethodsWe studied the brains of 447 older decedents participating in a clinical-autopsy cohort study. We deployed
Shahram Oveisgharan +6 more
doaj +1 more source
Neuroinflammation in Preclinical Alzheimer's Disease: A Review of Current Evidence [PDF]
, 2018 The pathology of sporadic Alzheimer’s disease (AD) may be present at mid-life and precede the prodromal and clinical dementia syndromes associated with the disorder by decades.
Raymont, Vanessa +2 more
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Case Report: Progressive Asymmetric Parkinsonism Secondary to CADASIL Without Dementia
Frontiers in Neurology, 2022 Parkinsonism is a rare phenotype of cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL), all of which involve cognitive decline. Normal cognition has not been reported in previous disease studies.
Weihang Guo +23 more
doaj +1 more source