Results 41 to 50 of about 435,882 (385)

Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation : a tale of the unexpected [PDF]

, 2020
ObjectiveTo assess the clinical, radiologic, myopathologic, and proteomic findings in a patient manifesting a multisystem proteinopathy due to a homozygous valosin-containing protein gene (VCP) mutation previously reported to be pathogenic in the ...
Azmi, A, Baets, J, Clemen, CS, De Bleecker, Jan, De Jonghe, P, De Ridder, W, Eichinger, L, Hofmann, A, Johnson, K, Maudsley, S, Schröder, R, Straub, V, Töpf, A   +12 more
core   +1 more source

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Proceedings of the National Academy of Sciences of the United States of America, 1983
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have been responsible for the toxicity.
Burns Rs, C. Chiueh, S. Markey, M. Ebert, D. Jacobowitz, I. Kopin   +5 more
semanticscholar   +1 more source

Postoperative and Postpartum Onset of Chronic Parkinsonism: Four Case Reports

International Journal of Medical Students, 2014
Background: Certain environmental exposures have been linked to the development of parkinsonism. We report four cases in which the onset of chronic parkinsonism occurred immediately or soon after surgery or childbirth.
Manish Ramani B., Marcie Rabin L., Roger Kurlan   +2 more
doaj   +3 more sources

Bromocriptine-associated ototoxicity [PDF]

, 2007
Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Ballantyne, J, Lanthier, PL, Morgan, MY
core   +1 more source

Modulation of Peripheral Mast Cell and Brain Microglia Axis via Kinase Inhibition

Metabolites
Background/Objectives: Kinase inhibition is a hot therapeutic strategy for several human diseases, including neurodegeneration. Tyrosine kinase c-KIT activates peripheral mast cells, while other kinases including Abelson (c-Abl) promotes autophagy and ...
Xiaoguang Liu, Michaeline Hebron, Kaluvu Balaraman, Louis Ballard, Kimberly Liu, Max Stevenson, Charbel Moussa   +6 more
doaj   +1 more source

Early predictors of mortality in parkinsonism and Parkinson disease

Neurology, 2018
Objective To examine mortality and associated risk factors, including possible effects of mild cognitive impairment, imaging, and CSF abnormalities, in a community-based population with incident parkinsonism and Parkinson disease.
David Bäckström, G. Granåsen, M. Domellöf, J. Linder, Susanna Jakobson Mo, K. Riklund, H. Zetterberg, K. Blennow, L. Forsgren   +8 more
semanticscholar   +1 more source

Mortality in Parkinson's disease : A systematic review and meta-analysis [PDF]

, 2014
© 2014 International Parkinson and Movement Disorder Society.Peer reviewedPublisher ...
Greenland S, Harbord RM, Laupacis A, Nobrega F   +3 more
core   +1 more source

MIND Diet Associated with Reduced Incidence and Delayed Progression of Parkinsonism in Old Age

The Journal of Nutrition, Health & Aging, 2018
BackgroundIn old age, motor impairments including parkinsonian signs are common, but treatment is lacking for many older adults. In this study, we examined the association of a diet specifically developed to promote brain health, called MIND ...
Puja Agarwal, Yamin Wang, A. Buchman, T. Holland, David A. Bennett, M. Morris   +5 more
semanticscholar   +1 more source

Rest tremor in Parkinson's disease: body distribution and time of appearance [PDF]

, 2017
Objective To assess body distribution and timing of appearance of rest tremor in Parkinson's disease. Methods Information was obtained by a computerized database containing historical information collected at the first visit and data collected during the
Custodero, Giacomo Emanuele, Defazio, Giovanni, Gigante, Angelo Fabio, Guido, Marco, Iliceto, Giovanni, Liuzzi, Daniele, Livrea, Paolo, Mancino, Paola Vincenza, Pellicciari, Roberta   +8 more
core   +1 more source

Localizing parkinsonism based on focal brain lesions

Brain : a journal of neurology, 2018
Bradykinesia, rigidity, and tremor frequently co-occur, a clinical syndrome known as parkinsonism. Because this syndrome is commonly seen in Parkinson's disease, symptoms are often attributed to cell loss in the substantia nigra.
J. Joutsa, A. Horn, Joey Hsu, M. Fox
semanticscholar   +1 more source