Results 61 to 70 of about 15,613 (254)

Hetrombopag Added to Cyclosporine as the First‐Line Treatment for Patients With Non‐Severe Aplastic Anemia: A Phase 2 Multicenter Trial

American Journal of Hematology, Volume 101, Issue 3, Page 467-476, March 2026.
ABSTRACT Non‐severe aplastic anemia (NSAA) is a heterogeneous bone marrow failure syndrome with limited standardized treatment options. Cyclosporine A (CsA) monotherapy often yields suboptimal responses, highlighting an unmet clinical need for more effective therapies.
Lele Zhang, Ruonan Li, Qian Liang, Weiwang Li, Hong Pan, Zhen Gao, Liwei Fang, Jingyu Zhao, Xiao Yu, Zhexiang Kuang, Neng Nie, Jianping Li, Jinbo Huang, Xin Zhao, Meili Ge, Yizhou Zheng, Jun Li, Hong Zhang, Jun Shi   +18 more
wiley   +1 more source

Dysregulation of Chemokine/Chemokine Receptor Axes and NK Cell Tissue Localization during Diseases. [PDF]

, 2016
Chemokines are small chemotactic molecules that play key roles in physiological and pathological conditions. Upon signaling via their specific receptors, chemokines regulate tissue mobilization and trafficking of a wide array of immune cells, including ...
Ali, Allegretti, Balabanian, Berahovich, Bernardini, Bernardini, Bielekova, Bolomsky, Bradfield, Broxmeyer, Burga, Calderon, Campbell, Campbell, Carlsten, Carrega, Carrega, Castriconi, Chan, Chiossone, Chuang, Clift, Contento, Cooper, Doncker, Eisenhardt, El-Sherbiny, Fehniger, Foxman, Gajewski, Gao, Gomez-Mouton, Gregoire, Gulino, Halama, Hanna, Hayakawa, Huntington, Huntington, Inngjerdingen, Ishibashi, Ju, Juelke, Kastrukoff, Kramp, Krug, Krumbholz, Lanier, Lode, Lopez-Verges, Lunemann, Mace, Maciejewski-Duval, Mailliard, Mantovani, Marcenaro, Marquardt, Martin, Martin-Fontecha, Martinez-Rodriguez, Mayol, Moustaki, Muller, Nagasawa, Nakashima, Nokihara, Ottaviani, Ouyang, O’Boyle, Pablos, Pachynski, Pak-Wittel, Parolini, Paust, Petit, Ponzetta, Ponzetta, Riva, Rodriguez-Martin, Romagnani, Sciume, Sechler, Serrano-Pertierra, Shimoda, Sohy, Sojka, Somanchi, Stabile, Stegmann, Stumm, Szpurka, Tham, Vanbervliet, Vandenbark, Vischer, Vitale, Watt, Watts, Wendel, Yokoyama, Zabel, Zlotnik   +101 more
core   +1 more source

The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

Haematologica, 2012
Background Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation.
Jeffrey J. Pu, Rong Hu, Galina L. Mukhina, Hetty E. Carraway, Michael A. McDevitt, Robert A. Brodsky   +5 more
doaj   +1 more source

Upregulation of Checkpoint Ligand Programmed Death-Ligand 1 in Patients with Paroxysmal Nocturnal Hemoglobinuria Explained by Proximal Complement Activation [PDF]

, 2022
Markus Anliker, Daniela Drees, Lorin Loacker, Susanne Häfner, Andrea Griesmacher, Gregor Hoermann, Vilmos Fux, Harald Schennach, Paul Hörtnagl, Arthur Dopler, Stefan Schmidt, Rosa Bellmann‐Weiler, Günter Weiß, Astrid Marx‐Hofmann, Sixten Körper, Britta Höchsmann, Hubert Schrezenmeier, Christoph Q. Schmidt   +17 more
openalex   +1 more source

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial

American Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth, Wilma Barcellini, Christine Ademokun, Junho Jang, Maria Luisa Lozano, David Valcarcel Ferreiras, Cristina Pascual‐Izquierdo, Shripad Chitnis, Sofiya Matviykiv, Alessandra Vitaliti, Chi Chen, Vasiliki Katsanou, Raghav Chawla, Hanny Al‐Samkari   +13 more
wiley   +1 more source

Heme induces endothelial tissue factor expression: Potential role in hemostatic activation in patients with hemolytic anemia [PDF]

, 2008
Objectives: We explored the possibility that heme, an inflammatory mediator and a product of intravascular hemolysis in patients with hemolytic anemia including sickle cell disease, could modulate hemostasis by an effect on endothelial tissue factor (TF)
Betal, Suhita G., Setty, Yamaja, Stuart, Marie J., Zhang, Jie   +3 more
core   +2 more sources

Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria. [PDF]

PLoS Computational Biology, 2018
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemolysis and a high risk of thrombosis, that is due to a deficiency in several cell surface proteins that prevent complement activation.
Nathaniel Mon Père, Tom Lenaerts, Jorge M Pacheco, David Dingli   +3 more
doaj   +1 more source

White Blood Cell Enumeration and Differential by Flow Cytometry: The ICSH WBC Reference Method

International Journal of Laboratory Hematology, Volume 48, Issue 1, Page 93-101, February 2026.
ABSTRACT Introduction The current reference method for the white blood cell (WBC) differential is manual smear review as outlined in CLSI H20‐A2. As with many manual methods, it suffers from a number of challenges including dependence upon the expertise of the interpreter, the quality of the smear and stain, when dysplastic features make cell ...
Benjamin D. Hedley, Michael Keeney, Peter Gambell, Chenxue Qu, Jenny Mao, Bruce H. Davis, Brent L. Wood   +6 more
wiley   +1 more source

Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells [PDF]

, 2014
Latently HIV-1-infected cells are recognized as the last barrier toward viral eradication and cure. To purge these cells, we combined a provirus stimulant with a blocker of human CD59, a key member of the regulators of complement activation, to trigger ...
Amet, Tohti, Byrd, Daniel, Desai, Mona, Gao, Jimin, Gupta, Samir, Hu, Ningjie, Lan, Jie, Shepherd, Nicole, Sun, Yongtao, Yang, Kai, Yu, Qigui   +10 more
core   +2 more sources

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

Haematologica, 2010
Background Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia characterized by intravascular hemolysis which has been demonstrated to be effectively controlled with eculizumab.
Anita Hill, Russell P. Rother, Louise Arnold, Richard Kelly, Matthew J. Cullen, Stephen J. Richards, Peter Hillmen   +6 more
doaj   +1 more source