Results 121 to 130 of about 176,756 (350)
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Recent Run II QCD Results from DO
, 2004 We present recent QCD results from the D0 experiment at the Fermilab Tevatron Collider in pp-bar collisions at sqrt(s)=1.96 TeV. Results are presented for the inclusive jet and dijet cross sections, a measurement of dijet azimuthal decorrelations ...
Wobisch, Markus
core +1 more source
Advanced Science, EarlyView.Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang +10 more
wiley +1 more source
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
Journal of Neuroinflammation, 2011 Background Amyloid β (Aβ) accumulates in Alzheimer's disease (AD) brain. Microglial activation also occurs in AD, and this inflammatory response may contribute to disease progression.
Kauppinen Tiina M +9 more
doaj +1 more source
Monte Carlo event generator validation and tuning for the LHC
, 2008 We summarise the motivation for, and the status of, the tools developed by CEDAR/MCnet for validating and tuning Monte Carlo event generators for the LHC against data from previous colliders.
Buckley, Andy +3 more
core +1 more source
Topotecan and Irinotecan as potential inhibitors of PARP-1
, 2023 Yueyi Bao, Yizhou Yu
openalex +2 more sources
Differential Localisation of PARP-1 N-Terminal Fragment in PARP-1+/+ and PARP-1−/− Murine Cells
Molecules and Cells, 2014 Human PARP family consists of 17 members of which PARP-1 is a prominent member and plays a key role in DNA repair pathways. It has an N-terminal DNA-binding domain (DBD) encompassing the nuclear localisation signal (NLS), central automodification domain and C-terminal catalytic domain. PARP-1 accounts for majority of poly-(ADP-ribose) polymer synthesis
Ida Rachel, Rajiah, Jeremy, Skepper
openaire +3 more sources
Advanced Science, EarlyView.A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du +18 more
wiley +1 more source