Results 251 to 260 of about 116,902 (309)

Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation

European Journal of Haematology, Volume 117, Issue 1, Page 132-143, July 2026.
ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Mamdouh Skafi, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology. [PDF]

Neoplasia
Zhu H, Shao J, Wang Y, Gu C, Liu J.
europepmc   +1 more source

Retraction: 3, 3'-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing Breast Cancer Cells. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Biomarker-driven maintenance therapy in extensive-stage-small cell lung cancer: evaluating the SWOG S1929 clinical trial. [PDF]

J Thorac Dis
Johnston T, Breadner D, Raphael J.
europepmc   +1 more source

Randomized clinical trial of an Acceptance and Commitment Therapy telehealth intervention ('REVITALIZE') to reduce fatigue interference in women with advanced ovarian cancer on PARP inhibitors: study protocol. [PDF]

BMC Cancer
Arch JJ, Uno H, Poort H, Slivjak E, Nealis MS, Park H, Wang I, Genung SR, Cronin A, Andorsky DJ, Havrilesky LJ, Penson RT, Mazina V, Widick P, Lefkowits C, Wright AA.   +15 more
europepmc   +1 more source

MOB2 Loss Sensitizes Lung Cancer Cells to PARP Inhibition Through p53-Dependent DNA Damage Signaling. [PDF]

Curr Issues Mol Biol
Gundogdu R.
europepmc   +1 more source

A disulfide-bridged single-stranded DNA nanotube for co-delivery of siRNA and chemotherapeutics in ovarian cancer therapy. [PDF]

Front Med (Lausanne)
Luo Y, Guo A, Sheng T, Han L, Gu C, Li X, Chen C, Shi X.   +7 more
europepmc   +1 more source

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Plant PARPs, PARGs and PARP-like Proteins

Current Protein & Peptide Science, 2016
Poly(ADP-ribos)ylation, originally described as a mechanism of DNA break repair, is now considered as part of a complex regulatory system involved in dynamic reorganization of chromatin structure, transcriptional control of gene expression and regulation of metabolism. In plants poly(ADP-ribos)ylation has received surprisingly little attention.
Julia P, Vainonen, Alexey, Shapiguzov, Aleksia, Vaattovaara, Jaakko, Kangasjärvi   +3 more
openaire   +3 more sources

The PARP superfamily

BioEssays, 2004
AbstractPoly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic ...
Amé, Jean-Christophe, Spenlehauer, Catherine, de Murcia, Gilbert   +2 more
openaire   +3 more sources

Ageing and PARP

Pharmacological Research, 2005
Poly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways.
Alexander, Bürkle, Jörg, Diefenbach, Christine, Brabeck, Sascha, Beneke   +3 more
openaire   +2 more sources