Results 141 to 150 of about 693,900 (279)

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

Loss of CHTF18-RFC2/5 leads to replicative gaps and sensitivity to PARP inhibitors. [PDF]

NAR Cancer
Buckley-Benbow L, Ozgencil M, Tardocchi A, Agnarelli A, Bellelli R.   +4 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

PARP inhibitors in the treatment of ovarian cancer: a narrative review. [PDF]

Transl Cancer Res
Wang Y, Li X, Yang Y, Lv X, Wang K, Li H, Liu X, Jin K, Gao M.   +8 more
europepmc   +1 more source

The effects of PARP inhibitors in the imiquimod-induced mouse model of psoriasis

A pikkelysömör egy krónikus gyulladásos bőrbetegség, amelyben a keratinociták fokozott proliferációja és zavart differenciációja figyelhető meg. A poli(ADP-ribóz) polimeráz (PARP) enzimek fontos szerepet játszanak a gyulladásos folyamatok szabályozásában,
Takács, Mátyás
core  

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

Autophagy impairs the sensitivity of Ewing sarcoma cells to PARP inhibitors. [PDF]

Cancer Chemother Pharmacol
Clausen J, Kocher D, Schadwinkel HM, Becker S, Milde T, Beck JF, Sonnemann J.   +6 more
europepmc   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

Preoperative PARP Inhibitors in Ovarian Cancer Trials: Connecting Molecular Oncology and Cytoreductive Surgery. [PDF]

Cancers (Basel)
Miedziarek C, Caputa P, Bochyński H, Zaborowski MP, Nowak-Markwitz E.   +4 more
europepmc   +1 more source